Clinical and immunological features in children with multisystem inflammatory syndrome associated with SARS-CoV-2

Jaxybayeva I. Boranbayeva R. Bulegenova M. Urazalieva N.
24 April 2023 Mattioli 1885

Acta Biomedica
2023 #94 Issue 2

Background and aim of the research: MIS-C is characterized by intense immune activation and increased production of cytokines. The aim of our study was to analyze the changes of cellular and humoral immune responses in children with MIS-C, depending on the severity of the disease. Methods: Clinical, hematological and immunological parameters in children with severe and extremely severe MIS-C were compared. The study included a total of 50 patients divided into 3 groups: 20 children with extremely severe MIS-C requiring ICU care (MIS-C ICU “+”); 15 children with severe MIS-C but not requiring ICU care (MIS-C ICU “-”); and a control group of 15 children who had previously had COVID-19 and didn’t have MIS-C (MIS-C “-”). Results: In patients with MIS-C requiring ICU care, heart and liver damage, hema-tological changes, and the development of severe complications such as edematous syndrome, polyserositis, DIC, and cardiogenic shock were statistically more common. Both groups of children with MIS-C had CD3+ T-cell lymphopenia and a decrease in CD95 expression. In the group of children with MIS-C requiring ICU care, a significant increase in the relative numbers of B-lymphocytes, CD3-HLA-DR+ and CD25 and a decrease of NK-cells was observed. Conclusions: Conditions requiring ICU care in children with MIS-C are associated with a more profound immune dysregulation, as evidenced by our data. (www.actabiomedica.it).

children , cytokines , ICU , immunophenotyping , MIS-C

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Scientific Center of Pediatrics and Pediatric Surgery, Almaty, Kazakhstan
Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan

Scientific Center of Pediatrics and Pediatric Surgery
Asfendiyarov Kazakh National Medical University

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