FREQUENCY DISTRIBUTION OF FOUR CYTOKINE GENE POLYMORPHISMS IN HEALTHY WESTERN KAZAKHSTAN POPULATION
РАСПРЕДЕЛЕНИЕ ЧАСТОТ ПОЛИМОРФИЗМОВ ЧЕТЫРЕХ ГЕНОВ ЦИТОКИНОВ В ЗДОРОВОЙ ПОПУЛЯЦИИ ЗАПАДНОГО КАЗАХСТАНА
Jarkenov T.А. Zairova S.Т. Sakhanova S.K.
2023Republican Unitary Enterprise Publishing house “Belorusskaja Nauka”
Proceedings of the National Academy of Sciences of Belarus, Medical Series
2023#20Issue 4347 - 352 pp.
This study investigated a range of gene polymorphisms encoding IL-1, IL-6, IL-10, and TNF-α ‒308 in 100 healthy unrelated Kazakhs using real-time PCR. The findings were compared with published data on other populations. The distribution of genotypes was consistent with the Hardy−Weinberg equilibrium. However, the frequency of cytokine genotypes observed in the Kazakh population showed similarities and differences compared to neighboring ethnic groups. The most noticeable differences compared with Iranians, Turks, Russians, and Chinese were observed in the distribution of IL-1, IL-6, and IL-10 genotypes. The frequency of the TNF-α ‒308 genotype differed only with the Iranian population. Thus, our study showed a link between cytokine gene polymorphism and ethnicity. These results may be of clinical relevance in understanding the prevalence of diseases in Kazakhstan.
allele frequencies , cytokines , gene polymorphism , Hardy−Weinberg equilibrium , Kazakh population , population study
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West Kazakhstan Marat Ospanov Medical University, 68, Maresyev Str., Aktobe, 030019, Kazakhstan
The Psychological Support Service, Military Institute of Air Defense Named after T. J., Begeldinov, 39, Aliya Moldagulova Ave., Aktobe, 030012, Kazakhstan
The Scientific and Practical Center, West Kazakhstan Marat Ospanov Medical University, 68, Maresyev Str., Aktobe, 030019, Kazakhstan
West Kazakhstan Marat Ospanov Medical University
The Psychological Support Service
The Scientific and Practical Center
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