Aspirin Intolerance in the Setting of Acute Coronary Syndrome: Case Report and Review of Literature
Janpaizov T. Ibraimova I. Zhumagulov E. Dauyey K.
2025National Scientific Medical Center
Journal of Clinical Medicine of Kazakhstan
2025#22Issue 261 - 63 pp.
Acute coronary syndrome (ACS) requires prompt intervention to prevent myocardial ischemia. This case report describes a patient’s clinical journey, highlighting the challenges associated with aspirin intolerance and the necessity of an alternative antithrombotic approach. The patient, who presented with ACS and a documented history of aspirin-induced asthma and angioedema, was unable to undergo standard dual antiplatelet therapy (DAPT) with aspirin. Given the urgency of intervention and failed prior aspirin desensitization, ticagrelor and rivaroxaban were selected as alternative agents. The patient underwent successful percutaneous coronary intervention (PCI) with stent placement and was managed postoperatively using a modified antithrombotic regimen. The case underscores the importance of individualized therapy in aspirin-intolerant ACS patients and suggests a viable alternative strategy for anticoagulation and platelet inhibition. Patient outcomes were favorable, demonstrating effective ischemic risk mitigation without aspirin-related hypersensitivity reactions.
acute coronary syndrome , aspirin intolerance , percutaneous coronary intervention
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Department of Interventional Cardiology and Arrhythmology, City Multidisciplinary Hospital No. 2, Astana, Kazakhstan
Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan
Department of Interventional Cardiology and Arrhythmology
Department of Medicine
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026