Activated Carbon/Pectin Composite Enterosorbent for Human Protection from Intoxication with Xenobiotics Pb(II) and Sodium Diclofenac
Jandosov J. Alavijeh M. Sultakhan S. Baimenov A. Bernardo M. Sakipova Z. Azat S. Lyubchyk S. Zhylybayeva N. Naurzbayeva G. Mansurov Z. Mikhalovsky S. Berillo D.
April-1 2022MDPI
Molecules
2022#27Issue 7
The use of enterosorbents—materials which can be administered orally and eliminate toxic substances from the gastrointestinal tract (GIT) by sorption—offers an attractive complementary protection of humans against acute and chronic poisoning. In this study, we report the results of developing a microgranulated binary biomedical preparation for oral use. It was designed with a core-shell structure based on pectin with low degree of esterification as the core, and nanoporous activated carbon produced from rice husk, AC-RH, as the shell, designated as AC-RH@pectin. The adsorption properties of the synthesized materials were studied in aqueous solutions for the removal of lead (II) nitrate as a representative of toxic polyvalent metals and sodium diclofenac as an example of a medicinal drug. The composite enterosorbent demonstrated high adsorption capacity for both adsorbates studied. Adsorption kinetics of lead and diclofenac adsorption by AC-RH, pectin, and AC-RH@pectin, fitted well a pseudo-second-order model. According to the Langmuir adsorption isotherm model, the best fitted isotherm model, the maximum adsorption capacity, qmax, of AC-RH@pectin for diclofenac and for lead (II) was 130.9 mg/g and 227.8 mg/g, respectively. Although qmax of AC-RH for diclofenac, 537.6 mg/g, and qmax of pectin for lead (II), 245.7 mg/g, were higher, the maximum adsorption capacity of AC-RH for lead (II), 52.7 mg/g, was much lower than that of the composite AC-RH@pectin and the adsorption capacity of pectin for diclofenac was negligible. Therefore, the composite material AC-RH@pectin demonstrated substantial efficiency of removing both species which potentially defines it as a more universal enterosorbent suitable for treating poisoning caused by substances of different chemical nature.
diclofenac adsorption , enterosorbent , lead adsorption , pectin , porous carbon
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School of Pharmacy, Asfendiyarov Kazakh National Medical University, 94, Tole bi Street, Almaty, 050000, Kazakhstan
Institute of Combustion Problems, 172, Bogenbay Batyr Street, Almaty, 050000, Kazakhstan
Pharmidex Pharmaceutical Services, 14, Hanover Street, London, W1S 1YH, United Kingdom
Chemistry Division, Al-Farabi Kazakh National University, 71, Al-Farabi Avenue, Almaty, 050040, Kazakhstan
National Laboratory Astana, Nazarbayev University, 53, Kabanbay Avenue, Nur-Sultan, 010000, Kazakhstan
LAQV/REQUIMTE, Departamento de Química (DQ), Faculdade de Ciências e Tecnologia (FCT), Universidade Nova de Lisboa (UNL), Caparica, 2829-516, Portugal
Laboratory of Engineering Profile, Satbayev University, Almaty, 050012, Kazakhstan
ANAMAD Ltd, Sussex Innovation Centre, Science Park Square, Falmer, Brighton, BN1 9SB, United Kingdom
Chuiko Institute of Surface Chemistry, National Academy of Sciences of Ukraine, 17, General Naumov Street, Kyiv, 03164, Ukraine
Atchabarov Research Institute of Fundamental and Applied Medicine, 94, Tole bi Street, Almaty, 050000, Kazakhstan
School of Pharmacy
Institute of Combustion Problems
Pharmidex Pharmaceutical Services
Chemistry Division
National Laboratory Astana
LAQV/REQUIMTE
Laboratory of Engineering Profile
ANAMAD Ltd
Chuiko Institute of Surface Chemistry
Atchabarov Research Institute of Fundamental and Applied Medicine
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