The effect of sodium butyrate enemas compared with placebo on disease activity, endoscopic scores, and histological and inflammatory parameters in inflammatory bowel diseases: A systematic review of randomised controlled trials
Wirkung von natriumbutyrat-einläufen im vergleich zu placebo auf die krankheitsaktivität, endoskopische scores, sowie histologische und inflammatorische parameter bei chronisch-entzündlichen darmerkrankungen: eine systematische übersicht randomisierter, kontrollierter studien
Jamka M. Kokot M. Kaczmarek N. Bermagambetova S. Nowak J.K. Walkowiak J.
1 August 2021S. Karger AG
Complementary Medicine Research
2021#28Issue 4344 - 356 pp.
Introduction: Administration of butyrate enemas might improve the health status of patients with inflammatory bowel disease (IBD). However, the results seem equivocal. Therefore, this systematic review aimed to assess the effect of sodium butyrate enemas on disease activity index (DAI), endoscopic scores, as well as histological and inflammatory parameters in IBD patients. Methods: The PubMed, Scopus, Web of Science, and Cochrane databases were searched. Randomised controlled trials published in English that assessed the effect of butyrate enemas on DAI, clinical symptoms, inflammatory markers, as well as histological and endoscopic scores in patients with Crohns disease (CD) and ulcerative colitis (UC) were included in the analysis. Results: Eight studies involving 227 UC patients were included in this analysis. Only one study reported significant differences in DAI between groups. Besides, butyrate treatment groups did not differ significantly from controls concerning the effect on endoscopic and histological scores. Moreover, butyrate enemas exerted a significant effect on few inflammatory parameters measured in colonic mucosal biopsies. Conclusion: The current evidence is limited and does not support the application of butyrate enemas in UC. There are no reliable data regarding the efficacy of butyrate enemas in CD. The systematic review protocol was registered in the PROSPERO database (CRD42020163654).
Butyrate , Crohns disease , Enema , Inflammatory bowel diseases , Ulcerative colitis
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Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland
West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan
Department of Pediatric Gastroenterology and Metabolic Diseases
West Kazakhstan Marat Ospanov State Medical University
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