Endurance training depletes antioxidant system but does not affect endothelial functions in women with abdominal obesity: A randomized trial with a comparison to endurance-strength training
Jamka M. Bogdański P. Krzyżanowska-Jankowska P. Miśkiewicz-Chotnicka A. Karolkiewicz J. Duś-żuchowska M. Mądry R. Lisowska A. Gotz-Więckowska A. Iskakova S. Walkowiak J. Mądry E.
2 April 2021MDPI
Journal of Clinical Medicine
2021#10Issue 8
Limited data suggested that inclusion of a strength component into endurance exercises might intensify the beneficial effect of training. However, the available data is limited. Therefore, we aimed to compare the effect of endurance and endurance-strength training on anthropometric parameters, endothelial function, arterial stiffness, antioxidant status, and inflammatory markers in abdominally obese women without serious comorbidities. A total of 101 women were recruited and randomly divided into endurance (n = 52) and endurance-strength (n = 49) groups. During the three-month intervention, both groups performed supervised sixty-minute training three times a week. All studied parameters were measured pre-and post-intervention period. In total, 85 women com-pleted the study. Both training significantly decreased anthropometric parameters. Besides, endurance training decreased endothelial nitric oxide synthase, central aortic systolic pressure, pulse wave velocity, glutathione (GSH), total antioxidant status (TAS), interleukin (IL) 8, matrix metallo-proteinase (MMP) 9, and tumor necrosis factor alpha, while endurance-strength training decreased MMP-2 concentrations, and increased IL-6, monocyte chemoattractant protein-1, and MMP-9 levels. We observed significant differences between groups for GSH, TAS, and MMP-9 levels. In summary, endurance and endurance-strength training did not differ in the impact on endothelial function and arterial stiffness. However, endurance training significantly depleted the antioxidant defense, sim-ultaneously reducing MMP-9 levels. The study was retrospectively registered with the German Clinical Trials Register within the number DRKS00019832.
Antioxidant status , Cardiovascular risk , Inflammatory markers , Oxidative stress
Text of the article Перейти на текст статьи
Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, Poznań, 60-572, Poland
Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Szamarzewskiego Str. 82, Poznań, 60-569, Poland
Department of Food and Nutrition, Poznan University of Physical Education, Królowej Jadwigi Str. 27/39, Poznań, 61-871, Poland
Department of Oncology, Poznan University of Medical Sciences, Szamarzewskiego Str. 84, Poznań, 60-569, Poland
Department of Clinical Auxology and Pediatric Nursing, Poznan University of Medical Sciences, Szpitalna Str. 27/33, Poznań, 60-572, Poland
Department of Ophthalmology, Poznan University of Medical Sciences, Szamarzewskiego Str. 84, Poznań, 60-569, Poland
Department of Pharmacology, Asfendiyarov Kazakh National Medical University, Tole Bi Str. 94, Almaty, 050000, Kazakhstan
Department of Physiology, Poznan University of Medical Sciences, Święcickiego Str. 6, Poznań, 60-781, Poland
Department of Pediatric Gastroenterology and Metabolic Diseases
Department of Treatment of Obesity
Department of Food and Nutrition
Department of Oncology
Department of Clinical Auxology and Pediatric Nursing
Department of Ophthalmology
Department of Pharmacology
Department of Physiology
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026