Synthesis and Investigation of Biological Activity of New Betulonic Acid Derivatives Containing 1,2,3-Triazole Fragments
Jalmakhanbetova R.I. Mukusheva G.K. Abdugalimov A.S. Zhumagalieva Z.Z. Dehaen W. Anthonissen S. Suleimen Y.M. Seidakhmetova R.B.
July 2024Multidisciplinary Digital Publishing Institute (MDPI)
Molecules
2024#29Issue 13
The results of this study showed that the compounds synthesized by the authors have significant potential due to their antibacterial and cytotoxic properties. The apparent antibacterial activity demonstrated by the compounds suggests that they are active antimicrobial agents against common microbial pathogens that cause various socially significant infectious diseases. Compound 6 showed pronounced antimicrobial activity against the Gram-positive test strain Staphylococcus aureus ATCC 6538, and compound 7 demonstrated pronounced antimicrobial activity against the Gram-negative test strain Escherichia coli ATCC 25922 (MIC = 6.3 µg/mL). This allowed us to consider these compounds to have great potential.
antimicrobial activity , betulonic acid , chemical transformation , cytotoxicity , lupane , natural product , spectroscopic method , synthesis , triterpenoid
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Department of Chemistry, Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Astana, 010000, Kazakhstan
Faculty of Chemistry, Karaganda Buketov University, Karaganda, 100024, Kazakhstan
Pedagogical Institute, Astana International University, Astana, 010000, Kazakhstan
Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven, B-3001, Belgium
Department of Chemistry, Chemical Technology and Ecology, Faculty of Technology, K. Kulazhanov Kazakh University of Technology and Business, Astana, 010000, Kazakhstan
Department of Clinical Pharmacology and Evidence-Based Medicine, Karaganda Medical University, Karaganda, 100024, Kazakhstan
Department of Chemistry
Faculty of Chemistry
Pedagogical Institute
Department of Chemistry
Department of Chemistry
Department of Clinical Pharmacology and Evidence-Based Medicine
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