Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma
Jain D. Murti Y. Khan W.U. Hossain R. Hossain M.N. Agrawal K.K. Ashraf R.A. Islam M.T. Janmeda P. Taheri Y. Alshehri M.M. Daştan S.D. Yeskaliyeva B. Kipchakbayeva A. Sharifi-Rad J. Cho W.C.
2021Hindawi Limited
Oxidative Medicine and Cellular Longevity
2021#2021
Hepatocellular carcinoma (HCC) is due to poor prognosis and lack of availability of effective treatment. Novel therapeutic strategies will be the fine tuning of intracellular ROS signaling to effectively deprive cells of ROS-induced tumor-promoting events. This review discusses the generation of ROS, the major signaling their modulation in therapeutics. We explore some of the major pathways involved in HCC, which include the VEGF, MAPK/ERK, mTOR, FGF, and Ser/Thr kinase pathways. In this review, we study cornerstone on natural bioactive compounds with their effect on hepatocarcinomas. Furthermore, we focus on oxidative stress and FDA-approved signaling pathway inhibitors, along with chemotherapy and radiotherapy enhancers which with early evidence of success. While more in vivo testing is required to confirm the findings presented here, our findings will aid future nonclinical, preclinical, and clinical studies with these compounds, as well as inspire medicinal chemistry scientists to conduct appropriate research on this promising natural compound and their derivatives.
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Department of Bioscience and Biotechnology, Banasthali Vidyapith, Rajasthan, India
Institute of Pharmaceutical Research, GLA University, Mathura, India
Key Laboratory for Sustainable Utilization of Tropical Bioresource, College of Tropical Crops Hainan University, Haikou, China
Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Dhaka, Bangladesh
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China
Faculty of Pharmacy, R.B.S. Engineering Technical Campus, Bichpuri, Agra, India
School of Pharmaceutical Science and Technology (SPST), Tianjin University, China
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Pharmaceutical Care Department, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia
Department of Biology, Faculty of Science, Sivas Cumhuriyet University, Sivas, 58140, Turkey
Beekeeping Development Application and Research Center, Sivas Cumhuriyet University, Sivas, 58140, Turkey
Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
Department of Bioscience and Biotechnology
Institute of Pharmaceutical Research
Key Laboratory for Sustainable Utilization of Tropical Bioresource
Department of Pharmacy
College of Chemistry
Faculty of Pharmacy
School of Pharmaceutical Science and Technology (SPST)
Phytochemistry Research Center
Pharmaceutical Care Department
Department of Biology
Beekeeping Development Application and Research Center
Faculty of Chemistry and Chemical Technology
Department of Clinical Oncology
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