Molecular Aspects of Allergen-Specific Immunotherapy in Patients with Seasonal Allergic Rhinitis
Izmailovich M. Semenova Y. Abdushukurova G. Mukhamejanova A. Dyussupova A. Faizova R. Gazaliyeva M. Akhvlediani L. Glushkova N. Kalmakhanov S. Bjørklund G.
February 2023MDPI
Cells
2023#12Issue 3
A systematic review and narrative synthesis of publications was undertaken to analyze the role of component-resolved diagnosis technology in identifying polysensitization for the provision of allergen-specific immunotherapy to patients with seasonal allergic rhinitis. A search of publications was carried out in electronic databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search helped to identify 568 publications, 12 of which were included in this review. Overall, 3302 patients were enrolled. The major finding was that component-resolved diagnostics change the choice of relevant allergens for allergen-specific immunotherapy in at least 50% of cases. Sensitization to allergen components differs with age, type of disease, and overall disease duration. Patients who had both bronchial asthma and allergic rhinitis were sensitized to a larger number of allergens than patients who had bronchial asthma alone.
allergen-specific immunotherapy , component-resolved diagnostics , cross-reactivity , molecular allergy diagnostics , seasonal allergic rhinitis , sensitization
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Department of Internal Diseases, Karaganda Medical University, Karaganda, 100008, Kazakhstan
School of Medicine, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan
Department of Therapy, Faculty of Postgraduate Medical Education, Shymkent Medical Institute, Shymkent, 160006, Kazakhstan
Department of Family Medicine No 2, Astana Medical University, Nur-Sultan, 010000, Kazakhstan
Department of General Medical Practice of Semey City, Semey Medical University, Semey, 071400, Kazakhstan
Clinical Work, Astana Medical University, Nur-Sultan, 010000, Kazakhstan
School of Medicine Health Sciences, BAU International University Batumi, Batumi, 6010, Georgia
Department of Epidemiology, Biostatistics Evidence Based Medicine, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Department Health Policy and Organization, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, 8610, Norway
Department of Internal Diseases
School of Medicine
Department of Therapy
Department of Family Medicine No 2
Department of General Medical Practice of Semey City
Clinical Work
School of Medicine Health Sciences
Department of Epidemiology
Department Health Policy and Organization
Council for Nutritional and Environmental Medicine (CONEM)
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