Artificial genetic polymers against human pathologies
Ivanov G.S. Tribulovich V.G. Pestov N.B. David T.I. Amoah A.-S. Korneenko T.V. Barlev N.A.
December 2022BioMed Central Ltd
Biology Direct
2022#17Issue 1
Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community. Due to their unique biophysical features these artificial hybrid polymers are now being employed in various areas of theranostics (therapy and diagnostics). The current review provides an overview of their structure, principles of rational design, and biophysical features as well as highlights the areas of their successful implementation in biology and biomedicine. Finally, the review discusses the areas of improvement that would allow their use as a new class of therapeutics in the future.
Locked nucleic acids , Peptide nucleic acids , Xenonucleic acids
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Institute of Cytology, Tikhoretsky Ave 4, Saint Petersburg, 194064, Russian Federation
St. Petersburg State Technological Institute (Technical University), Saint Petersburg, 190013, Russian Federation
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products, Moscow, 108819, Russian Federation
Phystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology, Moscow Region, Dolgoprudny, 141701, Russian Federation
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997, Russian Federation
Institute of Biomedical Chemistry, Moscow, 119121б, Russian Federation
School of Medicine, Nazarbayev University, Astana, 010000, Kazakhstan
Institute of Cytology
St. Petersburg State Technological Institute (Technical University)
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products
Phystech School of Biological and Medical Physics
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
Institute of Biomedical Chemistry
School of Medicine
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