THE ROLE OF THE VAGINAL MICROBIOTA IN THE PATHOGENESIS OF PRETERM PREMATURE BIRTH IN WOMEN WITH IC: A SYSTEMATIC REVIEW

Issenova S. Bakytkhan K. Malgazhdarova B. Bazarbayeva Z. Dzhardemaliyeva N. Zhaksylykova A. Skakova R. Attar R.
January 2025 Georgian Association of Business Press

Georgian Medical News
2025 #361 Issue 4 194 - 202 pp.

Background: Cervical insufficiency and vaginal microbiota imbalance impact preterm birth outcomes. Objectives: To examine the role of vaginal microbiota in prelabor rupture of membranes in women with cervical insufficiency, focusing on microbial profile, risk factors, biomarkers, management, and neonatal outcomes. Methods: This systematic review (2020-2025) analyzed 13 original studies written in English on vaginal microbiotas role in PROM in women with cervical insufficiency, retrieved via ProQuest, Web of Science, Scopus, Cochrane Library, PubMed, and Google Scholar, with bias evaluation using RoB 1 and ROBINS-I tools. Results: Key findings show that Lactobacillus depletion and increased pathogenic bacteria like Gardnerella, E. coli, and Mycoplasma are common in dysbiosis microbiota. Diagnostic criteria for cervical insufficiency include short cervix and cervical dilation, with cerclage and progesterone being common treatments. PROM typically occurs around 24 weeks gestation, often spontaneously, with risk factors including bacterial vaginosis, short cervix, and cervical insufficiency. Preterm birth rates vary (8.9% to 84%), with neonatal outcomes including respiratory distress and mortality. Some studies show up to 93% fetal survival, with MMP-8 and elevated inflammatory cytokines linked to microbial imbalance. Conclusions: Microbial dysbiosis in cervical insufficiency linked to preterm birth outcomes.

birth weight. , gestational age at birth , maternal outcomes , neonatal mortality , neonatal outcomes , Preterm birth rate

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Department of Obstetrics and Gynecology with a Course in Clinical Genetics, NJSC “Kazakh National Medical University named after S.D. Asfendiyarov”, Almaty, Kazakhstan
Department of Obstetrics and Gynecology with a Course in Clinical Genetics, NJSC “Kazakh National Medical University named after S.D. Asfendiyarov”, Almaty, Kazakhstan
Department of Obstetrics and Gynecology №2, NJSC “Astana Medical University”, Astana, Kazakhstan
Department of Obstetrics and Gynecology with a Course in Clinical Genetics, Asfendiyarov Kazakh National Medical University, NCJSC, Almaty, Kazakhstan
International Faculty, NJSC “Kazakh National Medical University named after S.D. Asfendiyarov”, Almaty, Kazakhstan
Obstetrician-gynecologist, Almaty, Kazakhstan
Department of Obstetrics and Gynecology with a Course in Clinical Genetics, NJSC “Kazakh National Medical University named after S.D. Asfendiyarov”, Almaty, Kazakhstan
Yeditepe University Koşuyolu Hospital, Yeditepe University Faculty of Medicine, Istanbul, Turkey

Department of Obstetrics and Gynecology with a Course in Clinical Genetics
Department of Obstetrics and Gynecology with a Course in Clinical Genetics
Department of Obstetrics and Gynecology №2
Department of Obstetrics and Gynecology with a Course in Clinical Genetics
International Faculty
Obstetrician-gynecologist
Department of Obstetrics and Gynecology with a Course in Clinical Genetics
Yeditepe University Koşuyolu Hospital

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