The crosstalk between dendritic cells, cytokine-induced killer cells and cancer cells from the perspective of combination therapy

Issabekova A. Zhumabekova M. Zhunussova M. Ogay V.
June 2021 Russian Open Medical Journal

Russian Open Medical Journal
2021 #10 Issue 2

Dendritic cells (DCs) are considered the most potent professional antigen-presenting cells (APCs) that elicit adaptive antitumour immunity. DCs integrate multiple environmental signals by efficiently processing tumour-associated antigens (TAAs) and migrating to draining lymph nodes (dLNs), where they present foreign antigens to T cells for priming. DCs thus serve as a major link between innate and adaptive immunity. Although DCs (mostly monocyte-derived DCs [mo-DCs]) have already been used in cancer therapies, such approaches have shown limited efficacy. Mo-DCs have the unique ability to present antigens to T cells in peripheral tissues. CD3+CD56+ cytokine-induced killer (CIK) cells are characterized by both MHC-restricted and MHC-unrestricted antitumour cytotoxicity against a broad range of cancer cells. This review presents an overview of the mechanisms by which mo-DCs and CIK cells’ interact with each other and with tumours. The maturation of DCs was identified as a crucial step in the development of effective DC-based vaccines against cancer. A further improved adoptive immunotherapy strategy involves a combination of mature mo-DCs and CIK cells. Combination therapy presents many opportunities for cancer treatment, as reported by a number of clinical trials. However, there is a lack of fundamental studies on the interaction of in vitro-generated mo-DCs with CIK cells. We discuss several methods of boosting DC-based vaccines and review the current knowledge of contact-dependent and cytokine-induced interactions of mo-DCs with CIK cells. We highlight that the combination of mo-DCs with CIK cells activates MHC-restricted and MHC-unrestricted immune responses.

CCR5 signalling , Cytokine-induced killer cells , Dendritic cells , Dendritic cells maturation , Heat-shock proteins

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Senior scientist, National Center For Biotechnology, Nur-Sultan, Kazakhstan
Bachelor, Junior scientist, National Center for Biotechnology, Nur-Sultan, Kazakhstan
Master, Junior scientist, National Center For Biotechnology, Nur-Sultan, Kazakhstan
Head of Stem Cell laboratory, National Center For Biotechnology, Nur-Sultan, Kazakhstan

Senior scientist
Bachelor
Master
Head of Stem Cell laboratory

10 лет помогаем публиковать статьи Международный издатель

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