Therapeutic strategies for rheumatic diseases and disorders: targeting redox imbalance and oxidative stress
Islam M.T. Sarkar C. Hossain R. Bhuia M.S. Mardare I. Kulbayeva M. Ydyrys A. Calina D. Habtemariam S. Kieliszek M. Sharifi-Rad J. Cho W.C.
August 2023Elsevier Masson s.r.l.
Biomedicine and Pharmacotherapy
2023#164
Rheumatic diseases and disorders (RDDs) are a group of chronic autoimmune diseases that are collectively called multicausal diseases. They have resulted from predisposing genetic profiles and exposure to a range of environmental, occupational and lifestyle risk factors. Other causative factors include bacterial and viral attacks, sexual habits, trauma, etc. In addition, numerous studies reported that redox imbalance is one of the most serious consequences of RDDs. For example, rheumatoid arthritis (RA) as a classic example of chronic RDDs is linked to oxidative stress. This paper summarizes the contributions of redox imbalance to RDDs. The findings suggest that establishing direct or indirect therapeutic strategies for RDDs requires a more in-depth understanding of the redox dysregulation in these diseases. For example, the recent awareness of the roles of peroxiredoxins (Prdxs, e.g. Prdx2, Prdx3) in RDDs provided one potential route of therapeutic intervention of these pathologies. Changes in stressful lifestyles and dietary habits may also provide additional benefits in the management of RDDs. Future studies should be directed to explore molecular interactions in redox regulations associated with RDDS and potential therapeutic interventions.
Free radicals , Oxidative stress , Redox regulation , Rheumatic diseases
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Department of Biophysics, Biomedicine and Neuroscience, Al-Farabi Kazakh National University, Al-Farabi Av. 71, Almaty, 050040, Kazakhstan
Biomedical Research Centre, Al-Farabi Kazakh National University, Al-Farabi ave. 71, Almaty, 050040, Kazakhstan
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Department of Food Biotechnology and Microbiology, Institute of Food Sciences, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159C, Warsaw, 02-776, Poland
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
Department of Pharmacy
Department of Pharmacology
Department of Public Health and Management
Department of Biophysics
Biomedical Research Centre
Department of Clinical Pharmacy
Pharmacognosy Research & Herbal Analysis Services UK
Department of Food Biotechnology and Microbiology
Facultad de Medicina
Department of Clinical Oncology
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