Neuropharmacological Effects of Quercetin: A Literature-Based Review
Islam M.S. Quispe C. Hossain R. Islam M.T. Al-Harrasi A. Al-Rawahi A. Martorell M. Mamurova A. Seilkhan A. Altybaeva N. Abdullayeva B. Docea A.O. Calina D. Sharifi-Rad J.
17 June 2021Frontiers Media S.A.
Frontiers in Pharmacology
2021#12
Quercetin (QUR) is a natural bioactive flavonoid that has been lately very studied for its beneficial properties in many pathologies. Its neuroprotective effects have been demonstrated in many in vitro studies, as well as in vivo animal experiments and human trials. QUR protects the organism against neurotoxic chemicals and also can prevent the evolution and development of neuronal injury and neurodegeneration. The present work aimed to summarize the literature about the neuroprotective effect of QUR using known database sources. Besides, this review focuses on the assessment of the potential utilization of QUR as a complementary or alternative medicine for preventing and treating neurodegenerative diseases. An up-to-date search was conducted in PubMed, Science Direct and Google Scholar for published work dealing with the neuroprotective effects of QUR against neurotoxic chemicals or in neuronal injury, and in the treatment of neurodegenerative diseases. Findings suggest that QUR possess neuropharmacological protective effects in neurodegenerative brain disorders such as Alzheimer’s disease, Amyloid β peptide, Parkinson’s disease, Huntingtons disease, multiple sclerosis, and amyotrophic lateral sclerosis. In summary, this review emphasizes the neuroprotective effects of QUR and its advantages in being used in complementary medicine for the prevention and treatment o of different neurodegenerative diseases. © Copyright
mechanisms , neural damage , neurodegenerative disorders , neuropharmacological effects , quercetin , signaling pathways
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Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh
Facultad de Ciencias de La Salud, Universidad Arturo Prat, Iquique, Chile
Natural and Medical Sciences Research Centre, University of Nizwa, Nizwa, Oman
Department of Nutrition and Dietetics, Faculty of Pharmacy, Centre for Healthy Living, University of Concepción, Concepción, Chile
Department of Biodiversity of Bioresources, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Educational program, Geography, Environment and Service sector, Abai Kazakh National Pedagogical University, Almaty, Kazakhstan
Biomedical Research Centre, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Molecular Biology and Genetics, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Pharmacy
Facultad de Ciencias de La Salud
Natural and Medical Sciences Research Centre
Department of Nutrition and Dietetics
Department of Biodiversity of Bioresources
Educational program
Biomedical Research Centre
Department of Molecular Biology and Genetics
Department of Toxicology
Department of Clinical Pharmacy
Phytochemistry Research Center
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