An updated overview of anticancer effects of alternariol and its derivatives: underlying molecular mechanisms
Islam M.T. Martorell M. González-Contreras C. Villagran M. Mardones L. Tynybekov B. Docea A.O. Abdull Razis A.F. Modu B. Calina D. Sharifi-Rad J.
2023Frontiers Media S.A.
Frontiers in Pharmacology
2023#14
Alternariol is a toxic metabolite of Alternaria fungi and studies have shown multiple potential pharmacological effects. To outline the anticancer effects and mechanisms of alternariol and its derivatives based on database reports, an updated search of PubMed/MedLine, ScienceDirect, Web of Science, and Scopus databases was performed with relevant keywords for published articles. The studies found to suggest that this mycotoxin and/or its derivatives have potential anticancer effects in many pharmacological preclinical test systems. Scientific reports indicate that alternariol and/or its derivatives exhibit anticancer through several pathways, including cytotoxic, reactive oxygen species leading to oxidative stress and mitochondrial dysfunction-linked cytotoxic effect, anti-inflammatory, cell cycle arrest, apoptotic cell death, genotoxic and mutagenic, anti-proliferative, autophagy, and estrogenic and clastogenic mechanisms. In light of these results, alternariol may be one of the hopeful chemotherapeutic agents. Copyright
alternariol , apoptosis , cancer , chemotherapy , cytotoxic effect , molecular targets , mycotoxin
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Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh
Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepción, Concepción, Chile
Centre for Healthy Living, University of Concepción, Concepción, Chile
Universidad de Concepción, Unidad de Desarrollo Tecnológico, UDT, Concepción, Chile
Biomedical Sciences Research Laboratory, Faculty of Medicine, Universidad Católica de la Santísima Concepción, Concepción, Chile
Department of Biodiversity of Bioresources, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia
Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia
Department of Biochemistry, Faculty of Science, University of Maiduguri, Maiduguri, Nigeria
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
Department of Pharmacy
Department of Nutrition and Dietetics
Centre for Healthy Living
Universidad de Concepción
Biomedical Sciences Research Laboratory
Department of Biodiversity of Bioresources
Department of Toxicology
Department of Food Science
Natural Medicines and Products Research Laboratory
Department of Biochemistry
Department of Clinical Pharmacy
Facultad de Medicina
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