MANAGEMENT STRATEGIES FOR THROMBOPHILIC PATIENTS UNDERGOING ASSISTED REPRODUCTIVE TECHNOLOGIES
Isenova S.S.H. Aripkhanova A.S. Sultanmuratova D.D. Kazybaeva A.S. Tileukul N.A. Boran A.M.
2023Bionika Media Ltd.
Akusherstvo i Ginekologiya (Russian Federation)
2023#2023Issue 115 - 10 pp.
Objective: To summarize the current data on optimal thromboprophylaxis in thrombophilic women undergoing in vitro fertilization (IVF) and embryo transfer, primarily with a focus on strategies for preventing venous thromboembolism (VTE); to discuss the possibility of preventing pregnancy complications in pregnant women with thrombophilia. Materials and methods: The databases and services, namely PubMed, Wiley, Scopus and Google scholar, have been searched for articles on thrombophilia and assisted reproductive technology-related pregnancy over the past 10 years. No restrictions were imposed on the design of the study. The search was carried out using MESH keywords. Results: Hereditary thrombophilia is a genetic condition that increases the risk of thromboembolic diseases, especially during pregnancy. However, it is not recommended to have routine screening for hereditary thrombophilia in asymptomatic patients. Pregnant women with a previous history of VTE or with first-line relatives with this disease should be screened for thrombophilia genes. Low molecular weight heparins and acetylsalicylic acid are effective methods of thromboprophylaxis; anticoagulant therapy should start in the first trimester and continue in the postpartum period. The patients with antiphospholipid syndrome may have a high antibody titer, these patients should refrain from IVF until the antibody titer decreases. Immunosuppressive therapy is an effective method of reducing antibodies. Conclusion: The history of repeated IVF failures and habitual miscarriage is not an indication for examination for thrombophilia genes; however, these women should be examined for the presence of antiphospholipid syndrome.
assisted reproductive technologies (ART) , in vitro fertilization (IVF) , low molecular weight heparins , pregnancy , thromboembolism , thrombophilia
Text of the article Перейти на текст статьи
Department of Obstetrics and Gynecology, Kazakh National Medical University named after S.D. Asfendiyarov, Almaty, Kazakhstan
Department of Obstetrics and Gynecology
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026