Prognostic significance of CD163 expression in colorectal cancer stroma: a retrospective cohort study

Imanbayev N.M. Iztleuov Y. Koyshybaev A. Zhumasheva A. Baizakov B. Kereyeva N. Satenova Z. Imanbayeva A. Tulyayeva A. Zholmukhamedova D. Aitmagambetova M. Zharylgapov A.
August 2025 Medical Association of Zenica-Doboj Canton

Medicinski Glasnik
2025 #22 Issue 2 253 - 257 pp.

Aim Colorectal cancer (CRC) ranks among the leading causes of cancer-related mortality worldwide, with significant incidence and mortality rates recorded in Kazakhstan. CRC poses a substantial healthcare burden, prompting investigations into novel prognostic markers. This study investigates the prognostic significance of CD163 expression in patients with colorectal cancer. Methods This retrospective cohort study was conducted in Aktobe, Kazakhstan, utilizing tissue microarrays from 175 patients diagnosed with TNM (Tumour, Node, Metastasis) stage I–IV colon adenocarcinoma. CD163 expression was assessed through immunohistochemistry. Kaplan-Meier survival analysis was employed to estimate 5-year overall survival, defined as the interval from diagnosis to death or last follow-up. Cox proportional hazard models were used to evaluate the relationship between CD163 expression levels and survival outcomes. Results High CD163 expression was linked to advanced disease stage of colorectal cancer (p<0.001), lymphovascular invasion (p<0.001), perineural invasion (p<0.001), and Collagen I>30%, A type (p<0.001). CD163 infiltration was a negative prognostic factor for colorectal cancer patients, with higher risks of death in the high CD163 expression group compared to the low CD163 group (HR=5.769, 95% CI 3.194 – 10.42; p<0.001). Conclusion The findings highlight CD163 as a potential prognostic biomarker in CRC, warranting further investigation into its mechanistic role and therapeutic implications.

adenocarcinoma , immunohistochemistry , survival analysis , tumour biomarkers , tumour micro-environment

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Department of Oncology, West Kazakhstan Marat Ospanov Medical University, Kazakhstan
Department of Radiology, West Kazakhstan Marat Ospanov Medical University, Kazakhstan
Department of Pathomorphology, Medical Centre of West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan

Department of Oncology
Department of Radiology
Department of Pathomorphology

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