Colorectal cancer and microbiota: systematic review
Imanbayev N. Iztleuov Y. Bekmukhambetov Y. Abdelazim I.A. Donayeva A. Amanzholkyzy A. Aigul Z. Aigerim I. Aslan Y.
2024Termedia Publishing House Ltd.
Przeglad Gastroenterologiczny
2024#19Issue 4380 - 396 pp.
Introduction: The gut microbiome maintains the mucus membrane barrier’s integrity, and it is modulated by the host’s immune system. Aim: To detect the effect of microbiota modulation using probiotics, prebiotics, symbiotics, and natural changes on colorectal cancers (CRCs). Methods: A PubMed search was conducted to retrieve the original and in vivo articles published in English language from 2010 until 2021 containing the following 1) CRCs, 2) CRCs treatment (i.e. surgical, chemotherapy, radiotherapy and/ or immunotherapy), and 3) microbiota probiotic(s), prebiotic(s), symbiotic(s), dysbiosis and/or nutritional treatment. A total of 198 PubMed records/articles were initially identified. 108 articles were excluded at the initial screening, and another 29 articles were excluded after reviewing the abstracts, and finally 61 studies were analysed for this systematic review. Results: The gut microbiota metabolites and (SCFAs) short-chain fatty acids (i.e. acetate and butyrate) have a protective effect against CRCs. SCFAs reduce the inflammatory cytokines, inhibit colonocyte proliferation, and promote malignant cell apoptosis. Butyrate maintains the integrity of the mucus membrane barrier and reduces intestinal mucosal inflammation. Reduced butyric acid level and increased inflammatory cytokines were observed after reduced Bacteroides fragilis and Bacteroides vulgatus species in the colon. Akkermansia muciniphila bacterium decreased in patients with CRCs. Conclusions: Prebiotics (i.e. inulin and resistant starch, SCFAs producers) and consumption of unprocessed plant products are useful for developing and maintaining healthy gut microbiota. The pro-, pre- and/or symbiotics may be useful when carefully selected for CRC patients, to restore beneficial gut microbiota and support treatment efficacy.
colorectal cancer , microbiota , review
Text of the article Перейти на текст статьи
Department of Oncology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Radiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Association of Individual Entrepreneurs and Legal Entities, National Chamber of Health, Astana, Kazakhstan
Department of Obstetrics and Gynaecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Pathomorphology, Medical Centre of West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of General Surgery, Medical Centre of West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Oncology
Department of Radiology
Association of Individual Entrepreneurs and Legal Entities
Department of Obstetrics and Gynaecology
Department of Normal Physiology
Department of Pathomorphology
Department of General Surgery
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026