The Role of Perinatal Complications in Neurodevelopmental Outcomes of ART-Conceived Children: Prognostic Model for Brain Immaturity
Ilmuratova S. Lokshin V. Nurgaliyeva Z. Kеmelbekov K. Kulniyazova G. Abdykalykova B. Seisebayeva R. Zhubanysheva K. Altynbayeva G. Mukhambetova G. Sadykova A. Marapov D. Nekhorosheva V. Manzhuova L.
October 2025Multidisciplinary Digital Publishing Institute (MDPI)
Biomedicines
2025#13Issue 10
Background/Objectives: Since the first successful birth following assisted reproductive technologies (ART) several decades ago, the global population of ART-conceived children has surpassed 13 million, with over 40,000 born in Kazakhstan. Despite this growth, questions remain about their long-term neurological outcomes, with existing studies reporting inconsistent findings. This study aimed to assess psychomotor development and the prevalence of nervous system pathologies among ART-conceived children in Kazakhstan and to develop a prognostic model for identifying pathological neurodevelopmental conditions. Methods: We studied 252 children (120 conceived via ART and 132 controls) using clinical examination and medical history data. Brain immaturity predictors were identified by univariate and multivariate logistic regression. Results: ART-conceived children exhibited a higher incidence of neurosonographic signs of brain structure immaturity. However, multivariate analysis indicated that ART itself was not an independent risk factor. Instead, perinatal complications—including prematurity, multiple pregnancy, low birth weight, asphyxia, and intrauterine infections—explained the observed differences. The prognostic model highlighted prematurity and preconceptional progesterone therapy as significant predictors. Overall neurological development did not differ significantly between the groups. Conclusions: These findings underscore the importance of early identification of perinatal risk factors and targeted preventive interventions to mitigate adverse neurodevelopmental outcomes in ART-conceived children.
assisted reproductive technologies , brain immaturity , neurodevelopment , perinatal complications , prognostic model
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International Clinical Centre of Reproduction “PERSONA”, Almaty, 050060, Kazakhstan
Department of Outpatient Pediatrics, School of Pediatrics, Kazakh National Medical University named after S.D.Asfendiyarov, Almaty, 050012, Kazakhstan
Department “Pediatrics-1”, JSC South Kazakhstan Medical Academy, Shymkent, 486019, Kazakhstan
Department of Fundamental Medicine, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Department of Obstetrics and Gynecology, School of General Medicine No. 2, Kazakh National Medical University named after S.D.Asfendiyarov, Almaty, 050012, Kazakhstan
Department of Neonatology, Kazakh National Medical University named after S.D.Asfendiyarov, Almaty, 050012, Kazakhstan
Scientific Center of Pediatrics and Pediatric Surgery, Almaty, 050012, Kazakhstan
Department of Nervous Diseases, Kazakh National Medical University named after S.D.Asfendiyarov, Almaty, 050012, Kazakhstan
Department of Infectious and Tropical Diseases, School of General Medicine No. 2, Kazakh National Medical University named after S.D.Asfendiyarov, Almaty, 050012, Kazakhstan
Department of Public Health, Economics and Health Care Management, Kazan State Medical Academy, Kazan, 420012, Russian Federation
Institute of Reproductive Medicine, Almaty, 050012, Kazakhstan
International Clinical Centre of Reproduction “PERSONA”
Department of Outpatient Pediatrics
Department “Pediatrics-1”
Department of Fundamental Medicine
Department of Obstetrics and Gynecology
Department of Neonatology
Scientific Center of Pediatrics and Pediatric Surgery
Department of Nervous Diseases
Department of Infectious and Tropical Diseases
Department of Public Health
Institute of Reproductive Medicine
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