Long-term outcomes of ICSI: Health assessment of children conceived through intracytoplasmic sperm injection
Ilmuratova S. Lokshin V. Manzhuova L. Nurgaliyeva Z. Marapov D. Mukhambetova G. Kalidinova A.
30 September 2025Kaz Med Print LLP
Reproductive Medicine (Central Asia)
2025#2025Issue 337 - 44 pp.
Relevance: The widespread use of intracytoplasmic sperm injection (ICSI) as part of assisted reproductive technologies (ART) requires a comprehensive assessment of its impact on childrens health. Despite existing research, data on the health of ICSI-conceived offspring remain controversial. The study aimed to analyze current data on the health of children born after ICSI to identify potential features of their general somatic, physical, and pubertal development, and assess the risks of endocrine system disorders and congenital malformations. Methods: We conducted a literature search in databases (Medline, Scopus, Web of Science, etc.) using key terms. Studies in English and Russian meeting the inclusion criteria were reviewed. Results: Over 30 years of ICSI application, data have been accumulated showing normal physical and cognitive development in children. However, potential risks were identified: metabolic disorders (obesity, insulin resistance), changes in reproductive parameters (FSH and inhibin B levels), and increased frequency of urogenital anomalies. Additionally, differences were observed in total sperm count, motility, and morphology. The conducted review allows us to conclude that existing studies do not fully explore the relationship between the etiology of paternal infertility and the health status of offspring after ICSI. This knowledge gap complicates the assessment of the risks of inheriting reproductive pathologies. Conclusion: Further research is needed to understand the long-term consequences of ICSI, particularly regarding the reproductive and endocrine health of offspring.
ART , endocrine disorders , ICSI , male infertility , offspring health , reproductive health
Text of the article Перейти на текст статьи
PERSONA International Clinical Center for Reproductology, Almaty, Kazakhstan
Scientific Center of Pediatrics and Pediatric Surgery, Almaty, Kazakhstan
Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Kazan State Medical Academy – branch of the Federal State Budgetary Educational Institution of Additional Professional Education RMANPO of the Ministry of Health of Russia, Kazan, Russian Federation
Ecomed Clinic, Almaty, Kazakhstan
PERSONA International Clinical Center for Reproductology
Scientific Center of Pediatrics and Pediatric Surgery
Asfendiyarov Kazakh National Medical University
Kazan State Medical Academy – branch of the Federal State Budgetary Educational Institution of Additional Professional Education RMANPO of the Ministry of Health of Russia
Ecomed Clinic
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026