Beyond the womb: a study on psychomotor skills and neuropathology in children born after assisted reproductive technologies
Ilmuratova S.Kh. Lokshin V.N. Manzhuova L.N. Nurgaliyeva Z.Zh. Kussainova F.A. Bazarbayeva А.A. Nekhorosheva V.A. Abshekenova A.T.
2024Dynasty Publishing House
Voprosy Ginekologii, Akusherstva i Perinatologii
2024#23Issue 45 - 11 pp.
Objective. To determine the indicators of psychomotor development and the frequency of nervous system diseases in children born after assisted reproductive technologies (ART). Patients and methods. A case-control study included 120 children born after ART and 132 naturally conceived children under 5 years of age. Inclusion criteria: a successful ART program between 2018 and 2023. Exclusion criteria: programs with donor oocytes/sperm, intrauterine insemination, and surrogacy. Medical history was collected in both groups, and examinations were performed, followed by statistical data analysis using IBM SPSS Statistics 26. Results. Сhildren conceived via ART began to walk with support statistically significantly earlier than naturally conceived children. However, the frequency of immaturity of brain structures detected by neurosonography was statistically significantly higher. The analysis revealed a correlation with other perinatal factors. When constructing a logistic regression with forced inclusion of ART in the regression model with significant risk factors, the use of ART itself lost its significance, which also confirms the absence of an independent effect of ART on the development of immaturity of brain structures. Conclusion. The use of ART does not negatively affect the neurological development of children. It is important to identify risk factors associated with infertility for timely intervention and rehabilitation of children at risk of developing cognitive diseases.
assisted reproductive technologies , attention deficit hyperactivity disorder , autism spectrum disorder , cerebral palsy , cognitive health , immaturity of brain structures , offspring , psychomotor development
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Kazakhstan Medical University “KSPH”, Almaty, Kazakhstan
International Clinical Center for Reproductive Medicine “PERSONA”, Almaty, Kazakhstan
Scientific Center of Pediatrics and Pediatric Surgery, Almaty, Kazakhstan
Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Institute of Reproductive Medicine, Almaty, Kazakhstan
Kazakhstan Medical University “KSPH”
International Clinical Center for Reproductive Medicine “PERSONA”
Scientific Center of Pediatrics and Pediatric Surgery
Asfendiyarov Kazakh National Medical University
Institute of Reproductive Medicine
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