Comparison of the performance of lipoperoxidation-antioxidant protection system in rats at different periods under immobilization stress effects
Ilderbayev O.Z. Zharmakhanova G.M. Okassova A.K. Nursafina A.Z. Ilderbayeva G.O.
2021Iran University of Medical Sciences
Medical Journal of the Islamic Republic of Iran
2021#35Issue 11 - 6 pp.
Background: Under physiological conditions, the activity of the formation of active oxygen is low. The activity of these processes is intensified under stress-induced situations. This study aimed to investigate the role of free-radical oxidation (FRO) in adrenal tissues and immunocompetent organs and cells in mature white rats after 6 hours of immobilization stress. Methods: The studies were performed on 40 White male rats of the Wistar line with a bodyweight of 200 to 240 g. Two series of experiments were conducted: I series: deter ination of indices in intact rats (10 rats); II series: determination of indices after a 6-hour immobilization stress action on them. Animals of II series were divided into 3 groups f 10 rats in each: group 1: those undergoing acute immobilization stress, withdrawal from the experiment in 1 hour; group 2: those undergoing acute immobilization stress, withdrawal from the experiment in 25 hours; and group 3: those undergoing acute immobilization stress, withdrawal from the experiment in 49 hours. The obtained data were processed by statistical methods with the help of the Biostat and Excel software packages. Results: In groups 1, 2, and 3, the anima s were simulated acute immobilization stre s by fixing the animals for 6 hours in bright light. The results of the conducted studies indicate changes in lipid peroxidation and antioxidant system (LPO-AOS) in case of immobilization stress-excitation. In devel ping free-radical pathology at immobilization stress-excitation, the more expressed disturbance of LPO-AOS, and accordingly the intensity of lipoperoxidation in the structural membrane of all investigated organs was high at the initial stage of exposure.Conclusion: At 49 hours after immobilization, stress less pronounced influence on the lipoperoxidation process was noted. The increase in the intensity of excessive lipoperoxidation testifies to the inhibited manifestat on of AOS in the organism.
Antioxidation , Free Radicals , Immobilization Stress , Lipid Peroxidation
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Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Nur-Sultan, Kazakhstan
Department of Natural Science Disciplines, West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan
Department of Physiological Disciplines, Semey Medical University, Semey, Kazakhstan
Faculty of Natural Sciences
Department of Natural Science Disciplines
Department of Physiological Disciplines
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