Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications
Ijaz S. Iqbal J. Abbasi B.A. Ullah Z. Yaseen T. Kanwal S. Mahmood T. Sydykbayeva S. Ydyrys A. Almarhoon Z.M. Sharifi-Rad J. Hano C. Calina D. Cho W.C.
June 2023Elsevier Masson s.r.l.
Biomedicine and Pharmacotherapy
2023#162
Cancer is still the leading cause of death worldwide, burdening the global medical system. Rosmarinic acid (RA) is among the first secondary metabolites discovered and it is a bioactive compound identified in plants such as Boraginaceae and Nepetoideae subfamilies of the Lamiaceae family, including Thymus masticmasti chinaythia koreana, Ocimum sanctum, and Hyptis pectinate. This updated review is to highlight the chemopreventive and chemotherapeutic effects of RA and its derivatives, thus providing valuable clues for the potential development of some complementary drugs in the treatment of cancers. Relevant information about RAs chemopreventive and chemotherapeutic effects and its derivatives were collected from electronic scientific databases, such as PubMed/Medline, Scopus, TRIP database, Web of Science, and Science Direct. The results of the studies showed numerous significant biological effects such as antiviral, antibacterial, anti-inflammatory, anti-tumour, antioxidant and antiangiogenic effects. Most of the studies on the anticancer potential with the corresponding mechanisms are still in the experimental preclinical stage and are missing evidence from clinical trials to support the research. To open new anticancer therapeutic perspectives of RA and its derivatives, future clinical studies must elucidate the molecular mechanisms and targets of action in more detail, the human toxic potential and adverse effects.
Anticancer mechanisms , Antitumor , Apoptosis , Cancer , Pharmacology , Phytochemistry , Rosmarinic acid
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Department of Plant Sciences, Faculty of Biological Sciences, Quaid-i-Azam University Islamabad, 45320, Pakistan
Department of Botany, Bacha Khan University, Khyber Pakhtunkhwa, Charsadda, 24420, Pakistan
Department of Botany, Rawalpindi Women University, 6th Road, Satellite Town, Rawalpindi, 46300, Pakistan
Department of Biology and Environmental Sciences, Allama Iqbal Open University, Islamabad, Pakistan
Higher School of Natural Sciences, Zhetysu University named after I.Zhansugurov, Taldykorgan, 040009, Kazakhstan
Biomedical Research Centre, Al-Farabi Kazakh National University, Al-Farabi ave. 71, 050040, Kazakhstan
Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
Laboratoire de Biologie Des Ligneux Et Des Grandes Cultures (LBLGC), INRA USC1328 Université ď Orléans, Orléans Cedex2, 45067, France
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, 200349, Romania
Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
Department of Plant Sciences
Department of Botany
Department of Botany
Department of Biology and Environmental Sciences
Higher School of Natural Sciences
Biomedical Research Centre
Department of Chemistry
Facultad de Medicina
Laboratoire de Biologie Des Ligneux Et Des Grandes Cultures (LBLGC)
Department of Clinical Pharmacy
Department of Clinical Oncology
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