Are we closer to achieving precision medicine for migraine treatment? A narrative review
Ihara K. Casillo F. Dahshan A. Genç H. Jusupova A. Karbozova K. Lee W. Liaw Y.C. Mavridis T. Park H.-K. Polat B. Unt T.H. Vashchenko N. Zhantleuova A. Pozo-Rosich P. Schwedt T.J.
September 2024SAGE Publications Ltd
Cephalalgia
2024#44Issue 9
Background: The term ‘precision medicine’ encompasses strategies to optimize diagnosis and outcome prediction and to tailor treatment for individual patients, in consideration of their unique characteristics. The greater availability of multifaceted datasets and strategies to model such data have made precision medicine increasingly possible in recent years. Precision medicine is especially needed in the migraine field since the response to migraine treatments is not universal amongst all individuals with migraine. Objective: To provide a narrative review describing contributions to achieving precision medicine for migraine treatment. Methods: A search of PubMed for English language articles of human participants published from 2005 to January 2024 was conducted to identify articles that reported research contributing to precision medicine for migraine treatment. The published literature was categorized and summarized according to the type of data that were included: clinical phenotypes, genomics, proteomics, physiologic measures, and brain imaging. Results: Published studies have investigated characteristics associated with acute and preventive treatment responses, such as nonsteroidal anti-inflammatory drugs, triptans, onabotulinumtoxinA, and anti-calcitonin gene-related peptide monoclonal antibodies, in patients with episodic or chronic migraine. There is evidence that clinical, genetic, epigenetic, proteomic, physiologic, and brain imaging features might associate with migraine treatment outcomes, although inconsistencies for such findings clearly exist. Conclusions: The published literature suggests that there are clinical and biological features which associate with, and might be useful for predicting, migraine treatment responses. To achieve precision medicine for migraine treatment, further research is needed that validates and expands on existing findings and tests the accuracy and value of migraine treatment prediction models in clinical settings.
genomics , headache , imaging , migraine , personalized medicine , precision medicine , prediction , proteomics , treatment
Text of the article Перейти на текст статьи
Department of Neurology, Keio University School of Medicine, Tokyo, Japan
Neurology Department, Japanese Red Cross Ashikaga Hospital, Ashikaga, Japan
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy
Department of Neurology, Cairo University, Cairo, Egypt
Department of Neurology, Gaziantep City Hospital, Gaziantep, Turkey
Department of Neurology and Clinical Genetics, Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan
Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea
Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
Department of Neurology, Tallaght University Hospital, The Adelaide and Meath Hospital, Dublin, incorporating the National Childrens Hospital (AMNCH), Dublin, Ireland
Department of Neurology, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Gyeonggi-do, Goyang, South Korea
Faculty of Medicine, Department of Neurology, Duzce University, Duzce, Turkey
Neurology Center, Neurology and Psychiatric Clinic, West-Tallinn Central Hospital, Tallinn, Estonia
Department of Neurology, Danish Headache Center, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark
Department of Biophysics, Biomedicine, and Neuroscience, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Headache & Craniofacial Pain Clinic, Department of Neurology, Vall d’Hebron University Hospital, Barcelona, Spain
Headache Research Group, Vall d’Hebron Institute of Research, Departament de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain
Department of Neurology, Mayo Clinic, Phoenix, AZ, United States
Department of Neurology
Neurology Department
Department of Medico-Surgical Sciences and Biotechnologies
Department of Neurology
Department of Neurology
Department of Neurology and Clinical Genetics
Department of Neurology
Institute of Clinical Medicine
Neurological Institute
Department of Neurology
Department of Neurology
Faculty of Medicine
Neurology Center
Department of Neurology
Department of Biophysics
Headache & Craniofacial Pain Clinic
Headache Research Group
Department of Neurology
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026