Synthesis, Properties and Spatial Structure of 4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine
Ibrayev M.K. Nurkenov O.A. Rakhimberlinova Z.B. Takibayeva A.T. Turdybekov D.M. Seilkhanov T.M. Issabayeva M.B. Kelmyalene A.A. Kezdikbayeva A.T. Mendibayeva A.Z.
January 2023MDPI
Plants
2023#12Issue 1
This article has studied the synthesis of a new derivative of the known alkaloid cytisine contained in the seeds of plants of Cytisus laburnum L. and Thermopsis lanceolata R.Br., both of the Lugiminosae family. The new compound has been obtained from two biologically active compounds, such as isoxazole and cytisine. It has been demonstrated that the reaction led to the single-stage method under very mild conditions to obtain 4-[(3,5-dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine. This class of compounds is promising for obtaining the new biologically active compounds. This article has examined, in detail, a structure with using the 1H and 13C NMR and two-dimensional NMR spectroscopy of COSY (1H-1H), HMQC (1H-13C) and HMBC (1H-13C). As a result, the homo- and heteronuclear spin-spin couplings should be established. The X-ray diffraction analysis has determined the spatial structure of a new derivative based on the cytisine alkaloid. Thus, its hemorheological activity has been studied.
13C , 1H , 2D NMR spectroscopy , alkaloid cytisine , hemorheological activity , spatial structure , sulfo-derivatives of azoles , X-ray diffraction analysis
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Abylkas Saginov Karaganda Technical University, Ave. N. Nazarbayev, 56, Karaganda, 100027, Kazakhstan
Faculty of Chemistry, Karaganda Buketov University, st. University 28, Karaganda, 100024, Kazakhstan
Institute of Organic Synthesis and Coal Chemistry of Republic of Kazakhstan, st. Alikhanov, 1, Karaganda, 100008, Kazakhstan
Laboratory of Engineering Profile NMR Spectroscopy, Sh. Ualikhanov Kokshetau University, Kokshetau, 020008, Kazakhstan
School of Pharmacy, Medical University of Karaganda, Karaganda, 100008, Kazakhstan
Abylkas Saginov Karaganda Technical University
Faculty of Chemistry
Institute of Organic Synthesis and Coal Chemistry of Republic of Kazakhstan
Laboratory of Engineering Profile NMR Spectroscopy
School of Pharmacy
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