Investigation of the antibacterial activity of Rhamnus cathartica L. and its anti-QS potential on Pseudomonas aeruginosa PAO1
Ibrahim B. Reis A. Arın U.E. Muhammed M.T. Önem E.
2025Taylor and Francis Ltd.
Natural Product Research
2025#39Issue 164762 - 4774 pp.
The study aims to evaluate the Quorum Sensing (QS) system inhibition against some Gram-positive and Gram-negative bacteria detected by molecular modeling of R. cathartica L. plant extract. R. cathartica L. methanol extract was evaluated in vitro. R. cathartica L. extract was observed to have antimicrobial activity against Gram-positive and Gram-negative bacteria at different rates (11.3 mm–16 mm). The inhibitory effect of R. cathartica L. extract on P. aeruginosa PAO1 (elastase 61%, pyocyanin 18%, and biofilm 61%) was recorded moderately. Phytochemical analysis revealed that the main component of the extract is kaempferol. Therefore, the binding potential of kaempferol on QS system receptors was investigated via molecular docking. Computational analysis showed that kaempferol can inhibit the QS system by preventing competitive ligands from connecting to LasR. It may provide a new way to use R. cathartica L. seed extract as a green antibacterial agent.
antimicrobial , molecular docking , phytochemical , plant-based , Quorum sensing , Rhamnus cathartica L
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Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Suleyman Demirel University, Isparta, Turkey
Department of Midical Microbiology, Faculty of Medical, Karadeniz Technical University Karadeniz, Turkey
Vocational School of Health Services, Suleyman Demirel University, Isparta, Turkey
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Suleyman Demirel University, Isparta, Kazakhstan
Department of Pharmaceutical Microbiology
Department of Midical Microbiology
Vocational School of Health Services
Department of Pharmaceutical Chemistry
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