The Molecular Mechanisms in Senescent Cells Induced by Natural Aging and Ionizing Radiation
Ibragimova M. Kussainova A. Aripova A. Bersimbaev R. Bulgakova O.
March 2024Multidisciplinary Digital Publishing Institute (MDPI)
Cells
2024#13Issue 6
This review discusses the relationship between cellular senescence and radiation exposure. Given the wide range of ionizing radiation sources encountered by people in professional and medical spheres, as well as the influence of natural background radiation, the question of the effect of radiation on biological processes, particularly on aging processes, remains highly relevant. The parallel relationship between natural and radiation-induced cellular senescence reveals the common aspects underlying these processes. Based on recent scientific data, the key points of the effects of ionizing radiation on cellular processes associated with aging, such as genome instability, mitochondrial dysfunction, altered expression of miRNAs, epigenetic profile, and manifestation of the senescence-associated secretory phenotype (SASP), are discussed. Unraveling the molecular mechanisms of cellular senescence can make a valuable contribution to the understanding of the molecular genetic basis of age-associated diseases in the context of environmental exposure.
cellular senescence , DNA damage , ionizing radiation , miRNAs , mitochondrial dysfunction , natural aging , SASP
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Department of General Biology and Genomics, Institute of Cell Biology and Biotechnology, L.N. Gumilyov Eurasian National University, Astana, 010008, Kazakhstan
Department of Health Sciences, University of Genova, Via Pastore 1, Genoa, 16132, Italy
Department of General Biology and Genomics
Department of Health Sciences
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026