Propolis: An update on its chemistry and pharmacological applications
Hossain R. Quispe C. Khan R.A. Saikat A.S.M. Ray P. Ongalbek D. Yeskaliyeva B. Jain D. Smeriglio A. Trombetta D. Kiani R. Kobarfard F. Mojgani N. Saffarian P. Ayatollahi S.A. Sarkar C. Islam M.T. Keriman D. Uçar A. Martorell M. Sureda A. Pintus G. Butnariu M. Sharifi-Rad J. Cho W.C.
December 2022BioMed Central Ltd
Chinese Medicine (United Kingdom)
2022#17Issue 1
Propolis, a resinous substance produced by honeybees from various plant sources, has been used for thousands of years in traditional medicine for several purposes all over the world. The precise composition of propolis varies according to plant source, seasons harvesting, geography, type of bee flora, climate changes, and honeybee species at the site of collection. This apiary product has broad clinical applications such as antioxidant, anti-inflammatory, antimicrobial, anticancer, analgesic, antidepressant, and anxiolytic as well asimmunomodulatory effects. It is also well known from traditional uses in treating purulent disorders, improving the wound healing, and alleviating many of the related discomforts. Even if its use was already widespread since ancient times, after the First and Second World War, it has grown even more as well as the studies to identify its chemical and pharmacological features, allowing to discriminate the qualities of propolis in terms of the chemical profile and relative biological activity based on the geographic place of origin. Recently, several in vitro and in vivo studies have been carried out and new insights into the pharmaceutical prospects of this bee product in the management of different disorders, have been highlighted. Specifically, the available literature confirms the efficacy of propolis and its bioactive compounds in the reduction of cancer progression, inhibition of bacterial and viral infections as well as mitigation of parasitic-related symptoms, paving the way to the use of propolis as an alternative approach to improve the human health. However, a more conscious use of propolis in terms of standardized extracts as well as new clinical studies are needed to substantiate these health claims.
Anti-inflammatory , Anticancer , Antioxidant , Bee glue , Bioactive compounds , Food preservative
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Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Dhaka, Gopalganj, 8100, Bangladesh
Facultad de Ciencias de La Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique, 1110939, Chile
Pharmacy Discipline, Life Science School, Khulna University, Khulna, 9280, Bangladesh
Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh
Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, China
Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Department of Bioscience and Biotechnology, Rajasthan, Banasthali Vidyapith, 304022, India
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Viale Ferdinando Stagno d’Alcontres 31, Messina, 98166, Italy
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Biotechnology, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran
Department of Pharmacognosy and Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Food Processing Department, Vocational School of Technical Sciences, Bingöl University, Bingöl, Turkey
Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, Chile
Universidad de Concepción, Unidad de Desarrollo Tecnológico, UDT, Concepción, 4070386, Chile
Research Group on Community Nutrition and Oxidative Stress, Laboratory of Physical Activity Sciences, and CIBEROBN - Physiopathology of Obesity and Nutrition, CB12/03/30038, University of Balearic Islands, Palma, Spain
Department of Medical Laboratory Sciences, College of Health Sciences and Sharjah Institute for Medical Research, University of Sharjah, Sharjah, 22272, United Arab Emirates
Department of Biomedical Sciences, University of Sassari, Sassari, 07100, Italy
Chemistry & Biochemistry Discipline, University of Life Sciences King Mihai I from Timisoara, Calea Aradului 119, Timis, 300645, Romania
Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
Department of Pharmacy
Facultad de Ciencias de La Salud
Pharmacy Discipline
Department of Biochemistry and Molecular Biology
Department of Biomedical Engineering
Faculty of Chemistry and Chemical Technology
Department of Bioscience and Biotechnology
Department of Chemical
Department of Biology
Phytochemistry Research Center
Department of Medicinal Chemistry
Department of Biotechnology
Department of Pharmacognosy and Biotechnology
Food Processing Department
Department of Nutrition and Dietetics
Universidad de Concepción
Research Group on Community Nutrition and Oxidative Stress
Department of Medical Laboratory Sciences
Department of Biomedical Sciences
Chemistry & Biochemistry Discipline
Department of Clinical Oncology
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