Lasia spinosa Chemical Composition and Therapeutic Potential: A Literature-Based Review
Hossain R. Quispe C. Herrera-Bravo J. Islam M.S. Sarkar C. Islam M.T. Martorell M. Cruz-Martins N. Al-Harrasi A. Al-Rawahi A. Sharifi-Rad J. Ibrayeva M. Daştan S.D. Alshehri M.M. Calina D. Cho W.C.
2021Hindawi Limited
Oxidative Medicine and Cellular Longevity
2021#2021
Lasia spinosa (L.) is used ethnobotanically for the treatment of various diseases, including rheumatoid arthritis, inflammation of the lungs, bleeding cough, hemorrhoids, intestinal diseases, stomach pain, and uterine cancer. This review is aimed at summarizing phytochemistry and pharmacological data with their molecular mechanisms of action. A search was performed in databases such as PubMed, Science Direct, and Google Scholar using the keywords: Lasia spinosa,then combined with ethnopharmacological use,phytochemistry,and pharmacological activity.This updated review included studies with in vitro, ex vivo, and in vivo experiments with compounds of known concentration and highlighted pharmacological mechanisms. The research results showed that L. spinosa contains many important nutritional and phytochemical components such as alkanes, aldehydes, alkaloids, carotenoids, flavonoids, fatty acids, ketones, lignans, phenolics, terpenoids, steroids, and volatile oil with excellent bioactivity. The importance of this review lies in the fact that scientific pharmacological evidence supports the fact that the plant has antioxidant, anti-inflammatory, antimicrobial, cytotoxic, antidiarrheal, antihelminthic, antidiabetic, antihyperlipidemic, and antinociceptive effects, while protecting the gastrointestinal system and reproductive. Regarding future toxicological and safety data, more research is needed, including studies on human subjects. In light of these data, L. spinosa can be considered a medicinal plant with effective bioactives for the adjuvant treatment of various diseases in humans.
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Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh
Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique, 1110939, Chile
Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Chile
Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de la Frontera, Temuco, 4811230, Chile
Department of Nutrition and Dietetics, Faculty of Pharmacy, Centre for Healthy Living, University of Concepción, Concepción, 4070386, Chile
Universidad de Concepción, Unidad de Desarrollo Tecnológico, UDT, Concepción, 4070386, Chile
Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto, Portugal
Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal
Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU), Rua Central de Gandra, 1317, Gandra, 4585-116, Portugal
TOXRUN-Toxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, Gandra, 4585-116, Portugal
Natural and Medical Sciences Research Centre, University of Nizwa, Birkat Almouz, 616, Oman
Facultad de Medicina, Universidad Del Azuay, Cuenca, Ecuador
Faculty of Science and Technology, The Caspian University of Technology and Engineering Named after Sh. Yessenov, Aktau, Kazakhstan
Department of Biology, Faculty of Science, Sivas Cumhuriyet University, Sivas, 58140, Turkey
Beekeeping Development Application and Research Center, Sivas Cumhuriyet University, Sivas, 58140, Turkey
Pharmaceutical Care Department, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, 200349, Romania
Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
Department of Pharmacy
Facultad de Ciencias de la Salud
Departamento de Ciencias Básicas
Center of Molecular Biology and Pharmacogenetics
Department of Nutrition and Dietetics
Universidad de Concepción
Department of Biomedicine
Institute for Research and Innovation in Health (i3S)
Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU)
TOXRUN-Toxicology Research Unit
Natural and Medical Sciences Research Centre
Facultad de Medicina
Faculty of Science and Technology
Department of Biology
Beekeeping Development Application and Research Center
Pharmaceutical Care Department
Department of Clinical Pharmacy
Department of Clinical Oncology
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