Population genomics of Central Asian peoples unveil ancient Trans-Eurasian genetic admixture and cultural exchanges
He G. Wang M. Luo L. Sun Q. Yuan H. Lv H. Feng Y. Liu X. Cheng J. Bu F. Zhabagin M. Yuan H. Liu C. Xu S.
November 2024Elsevier B.V.
hLife
2024#2Issue 11554 - 562 pp.
Central Asia, a crucible of prehistoric and historical Trans-Eurasian interactions, has been pivotal in shaping cultural exchanges, population dynamics, and genetic admixture. Recent insights from ancient DNA studies have shed light on the extensive population turnover within this region, encompassing a spectrum of groups from Paleolithic hunter-gatherers to Holocene herders and the nomadic pastoralist empires of historical times. The genomic analysis of ancient pathogens across the Eurasian steppe has further deepened our understanding of pathogen origins, clonal expansions, and the intricate processes of host-pathogen coevolution in relation to varying pathogen exposures and their spread. We consolidate the latest findings pertaining to the ancient human and pathogen genomes of Central Asia, elucidating their profound influence on the genomic tapestry of contemporary Central Asians. A notable gap in the current genomic databases for Central Asia is underscored, particularly within the scope of genomics-driven precision medicine. We stress the urgent need for the development of extensive, region-specific genomic resources that hold promise for revealing the genetic blueprints underlying human traits and diseases, refining polygenic scoring models for predictive medicine, and bolstering genomic research endeavors across Central Asia.
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Center for Archaeological Science, Sichuan University, Sichuan, China
Institute of Rare Diseases, West China Hospital of Sichuan University, Sichuan University, Sichuan, China
Department of Forensic Medicine, College of Basic Medicine, Chongqing Medical University, Chongqing, China
Anti-Drug Technology Center of Guangdong Province, Guangdong, China
National Center for Biotechnology, Nur-Sultan, Kazakhstan
Center for Evolutionary Biology, School of Life Sciences, Fudan University, Shanghai, China
School of Life Science and Technology, ShanghaiTech University, Shanghai, China
Center for Archaeological Science
Institute of Rare Diseases
Department of Forensic Medicine
Anti-Drug Technology Center of Guangdong Province
National Center for Biotechnology
Center for Evolutionary Biology
School of Life Science and Technology
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