Silver(I) triflate-catalyzed post-Ugi synthesis of pyrazolodiazepines
Hasan M. Peshkov A.A. Shah S.A.A. Belyaev A. Lim C.-K. Wang S. Peshkov V.A.
2025Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
Beilstein Journal of Organic Chemistry
2025#21915 - 925 pp.
A silver(I) triflate-catalyzed post-Ugi assembly of novel pyrazolo[1,5-a][1,4]diazepine scaffolds is reported offering high yields (up to 98%) under mild conditions. The synthetic sequence involves the Ugi four-component reaction (U4CR) of pyrazole-3-carbaldehydes, primary amines, 3-substituted propiolic acids, and isocyanides, followed by a silver(I) triflate-catalyzed intramolecular heteroannulation of the resulting pyrazole-tethered propargylamides occurring in a 7-endo-dig fashion. The approach is scalable and tolerates a diverse range of substitution patterns.
heterocycles , post-MCR transformations , pyrazolodiazepines , silver catalysis , Ugi reaction
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College of Chemistry Chemical Engineering and Material Science, Soochow University, Suzhou, 215123, China
Department of Chemistry, School of Sciences and Humanities, Nazarbayev University, Astana, 010000, Kazakhstan
Department of Chemistry, University of Eastern Finland, Joensuu, FI-80101, Finland
Department of Chemical and Materials Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Astana, 010000, Kazakhstan
College of Chemistry Chemical Engineering and Material Science
Department of Chemistry
Department of Chemistry
Department of Chemical and Materials Engineering
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