Somatic Copy Number Alterations in Human Cancers: An Analysis of Publicly Available Data From The Cancer Genome Atlas
Harbers L. Agostini F. Nicos M. Poddighe D. Bienko M. Crosetto N.
28 July 2021Frontiers Media S.A.
Frontiers in Oncology
2021#11
Somatic copy number alterations (SCNAs) are a pervasive trait of human cancers that contributes to tumorigenesis by affecting the dosage of multiple genes at the same time. In the past decade, The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) initiatives have generated and made publicly available SCNA genomic profiles from thousands of tumor samples across multiple cancer types. Here, we present a comprehensive analysis of 853,218 SCNAs across 10,729 tumor samples belonging to 32 cancer types using TCGA data. We then discuss current models for how SCNAs likely arise during carcinogenesis and how genomic SCNA profiles can inform clinical practice. Lastly, we highlight open questions in the field of cancer-associated SCNAs. © Copyright
3D genome , cancer , copy number alterations , cosmic genes , TCGA
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Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Bienko-Crosetto Lab, Science for Life Laboratory, Stockholm, Sweden
Department of Pneumonology, Oncology and Allergology, Medical University of Lublin, Lublin, Poland
Department of Medicine, Nazarbayev University School of Medicine, Nur-Sultan, Kazakhstan
Clinical Academic Department of Pediatrics, National Research Center for Maternal and Child Health, University Medical Center, Nur-Sultan, Kazakhstan
Division of Genome Biology
Bienko-Crosetto Lab
Department of Pneumonology
Department of Medicine
Clinical Academic Department of Pediatrics
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