HLA allele and haplotype frequencies in Kazakhstani Russians and their relationship with other populations

Hajjej A. Abdrakhmanova S. Turganbekova A. Almawi W.Y.
March 2023 John Wiley and Sons Inc

HLA
2023 #101 Issue 3 249 - 261 pp.

HLA class I and class II genotypes from 947 Kazakhstani individuals of Russian origin were analyzed for investigating their most likely origin. The results were compared with similar data from other Russians (East and West), and also Worldwide populations, using standard genetic distances, neighbor-joining dendrograms, correspondence and haplotype analysis. Of the five HLA loci analyzed (HLA-A, HLA-C, HLA-B, HLA-DRB1, and HLA-DQB1) genotyped, 216 HLA alleles were identified. The most frequent alleles were A*02:01 (26.5%), B*07:02 (11.1%), C*04:01 (13.5%) and C*06:02 (12.1%), DRB1*07:01 (13.8%) and DRB1*15:01 (12.2%), and DQB1*03:01 (19.7%). Significant linkage disequilibrium was noted between all HLA pairs. DRB1*15:01 ~ DQB1*06:02 (10.5%), B*07:02 ~ C*07:02 (10.0%), B*07:02 ~ DRB1*15:01 (6.3%), and A*01:01 ~ B*08:01 (4.5%) were the most frequent two-locus haplotypes identified. Subsequent analyses showed that Kazakhstani Russians were closely related to West Russia-residing populations (Northwest Slavic, Vologda, Chelyabinsk, Moscow), East Europeans (Belarus Brest, Ukraine, Poland) and Scandinavians (Swedish, Finns), but distinct from East Russia-residing populations (Tuvians, Siberians from Chukotka, Kamchatka, and Ulchi) and East Mediterraneans (Levantines, Turks, North Macedonians, Albanians), and East Asians (Koreans, Japanese, Taiwanese, Mongolians). These results are in accordance with historical data indicating that the Russians of central Asia originate mainly from European Russia during the migratory flow of 18th and 19th centuries.

alleles , genotypes , haplotypes , HLA , Kazakhstan , Russia

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Department of Immunogenetics, National Blood Transfusion Center, Tunis, Tunisia
Research and Production Center of Transfusion, Kazakhstan Ministry of Health, Astana, Kazakhstan
Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, Kazakhstan
Faculty of Sciences, El-Manar University, Tunis, Tunisia

Department of Immunogenetics
Research and Production Center of Transfusion
Department of Biomedical Sciences
Faculty of Sciences

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