Wound healing and anti-inflammatory effects of recombinant human angiogenin
Ранозаживляющее и противовоспалительное действие рекомбинантного ангиогенина человека
Gulyayev A.E. Shulgau Z.T. Sergazy Sh.D. Yurina N.V. Goryachkin A.M. Bogachev S.S. Proskurina A.S.
2022National Electronic-Information Consortium (NEICON)
BIOpreparations. Prevention, Diagnosis, Treatment
2022#22Issue 3293 - 307 pp.
New effective wound healing agents are a priority for modern clinical pharmacology. A promising approach would be to develop medicinal products that promote angiogenesis, which is a critical step in wound healing. The aim of the study was to evaluate the wound healing effect of a medicinal product based on recombinant human angiogenin in gel form in various experimental models. Materials and methods: white outbred male rats were used as experimental animals. The study compared healing effects of a regenerating product containing recombinant human angiogenin (0.0025%) in gel form and a reference product in full-thickness excision, incision, and burn wound models. The healing effect of the test product in treating chronic wounds was assessed in a model of alloxan-induced diabetes mellitus. The anti-inflammatory effect of the test product containing recombinant human angiogenin was compared with that of another reference product in a model of adjuvant-induced arthritis. Results: according to the study, the test product based on recombinant human angiogenin exerts higher wound healing effect in treating excision, incision, and burn wounds than the reference product (Solcoseryl gel). Being applied, the test product intensifies tissue repair in chronic wounds in the model of alloxan-induced diabetes. The dissociation of necrotic tissues and the progression towards epithelialisation at wound edges are more rapid. The anti-inflammatory effect of the test product based on recombinant human angiogenin is comparable with that of the reference product (Diclofenac gel). Conclusions: the test product based on recombinant human angiogenin in gel form was found to have pronounced wound healing and anti-inflammatory effects comparable with those of reference products.
adjuvant-induced arthritis , alloxan-induced diabetes mellitus , anti-inflammatory agent , burn wound , excision wound , incision wound , recombinant human angiogenin
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National Center for Biotechnology, 13/5 Kurgalzhynskoye Rd, Nur-Sultan, 010000, Kazakhstan
National Laboratory Astana, Nazarbayev University, 53 Kabanbay batyr Ave, Nur-Sultan, 010000, Kazakhstan
Regional Center for High Medical Technologies, 71/1 Frunze St., Novosibirsk, 630112, Russian Federation
Novosibirsk State Medical University, 52 Krasnyj Ave, Novosibirsk, 630091, Russian Federation
Institute of Cytology and Genetics, Siberian Branch, The Russian Academy of Sciences, 10 Academician Lavrentiev Ave, Novosibirsk, 630090, Russian Federation
National Center for Biotechnology
National Laboratory Astana
Regional Center for High Medical Technologies
Novosibirsk State Medical University
Institute of Cytology and Genetics
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