Development of W-Type Four-Core Fiber-Based WaveFlex Sensor for Enhanced Detection of Shigella Sonnei Bacteria Using Engineered Nanomaterials

Gu C. Singh R. Li G. Wang Q. Liu F.-Z. Min R. Tosi D. Zhang B. Kumar S.
2024 Institute of Electrical and Electronics Engineers Inc.

Journal of Lightwave Technology
2024 #42 Issue 14 5055 - 5067 pp.

Shigella, a highly infectious and pathogenic Gram-negative bacterium, is widely prevalent in everyday food items, prompting significant research due to its potential hazards. Addressing the need for Shigella detection, this study introduces a WaveFlex biosensor based on localized surface plasmon resonance (LSPR) using fiber optics. The sensor is tailored to detect a specific subspecies of Shigella, specifically Shigella sonnei (S. sonnei). It is fabricated using a combination of multimode fiber (MMF) and four-core fiber (FCF), creating a core-mismatched W-type fiber structure designed for efficient mode coupling. Furthermore, this sensor is enhanced with the utilization of nanomaterials, including cerium oxide nanorods (CeO₂-NRs), zinc oxide nanowires (ZnO-NWs), and copper selenide@gold nanocomposites (Cu₃Se₂@Au-NCs). CeO₂-NRs and ZnO-NWs contribute to improve biocompatibility and increase surface area for antibody functionalization, while Cu₃Se₂@Au-NCs promote the LSPR effect and enhance sensing performance. To enhance specificity, the optical fiber coated with these engineered nanomaterials is functionalized with S. sonnei antibody. The results of this work showcase the effective detection of Shigella bacteria by the proposed WaveFlex sensor, offering exceptional sensitivity (0.28 nm/(CFU/mL)), a low limit of detection (LoD) of 0.96 CFU/mL, and a swift detection time of 10 minutes. These findings underscore the sensors potential for widespread applications in areas such as food safety, medical diagnostics, and environmental monitoring. This study significantly advances bacterial detection technology and contributes to the assurance of public health and food safety.

Engineered nanomaterials , food safety , four-core fiber , S. sonnei , W-type fiber , WaveFlex biosensor

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Koneru Lakshmaiah Education Foundation, Department of Biotechnology, Andhra Pradesh, Vaddeswaram, 522302, India
Liaocheng University, Liaocheng Peoples Hospital, Medical College, Liaocheng, 252000, China
Beijing Normal University, Center for Cognition and Neuroergonomics, State Key Laboratory of Cognitive Neuroscience and Learning, Zhuhai, 519087, China
Nazarbayev University, Department of Electrical and Computer Engineering, Astana, 010000, Kazakhstan
Koneru Lakshmaiah Education Foundation, Department of Electronics and Communication Engineering, Department, Andhra Pradesh, Vaddeswaram, 522302, India
Liaocheng University, Shandong Key Laboratory of Optical Communication Science and Technology, School of Physics Science and Information Technology, Liaocheng, 252059, China

Koneru Lakshmaiah Education Foundation
Liaocheng University
Beijing Normal University
Nazarbayev University
Koneru Lakshmaiah Education Foundation
Liaocheng University

10 лет помогаем публиковать статьи Международный издатель

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