The Role of the Inflammatory Process in the Development of Poststroke Cognitive Impairments

Grigolashvili M.A. Mustafina R.M.
January 2022 Springer

Neuroscience and Behavioral Physiology
2022 #52 Issue 1 39 - 44 pp.

Poststroke cognitive impairments (PSCI) are a common complication of stroke. Each year, about 8–15% of cases of PSCI progress to the level of dementia, leading to loss of independence and occupational and social maladjustment, which in turn significantly degrades quality of life and decreases the patient’s rehabilitation potential. Many experimental and clinical studies indicate that the inflammatory process plays an important role in the development of PSCI. Previously published work addressed the interaction between inflammatory markers and PSCI, and results on particular biomarkers were contradictory. Thus, inflammatory markers such as interleukin (IL)-8, IL-12, and erythrocyte sedimentation rate (ESR) had tight connections with the development of PSCI. Increases in ESR were linked with more severe PSCI, especially in patients with memory impairment. The existence of a link between markers such as interferon-γ (IFN-γ) and tumor necrosis factor (TNF-α) and PSCI has not been confirmed. Ambiguous results were obtained for IL-1β, IL-6, IL-10, and C-reactive protein. Thus, the inflammatory process plays an important role in the development of PSCI and includes a number of complex reactions, whose combined effects induce neuron damage and synapse loss, which ultimately leads to cognitive impairment.

inflammation markers , inflammatory process , poststroke cognitive impairment , stroke

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Karaganda Medical University, Karaganda, Kazakhstan

Karaganda Medical University

10 лет помогаем публиковать статьи Международный издатель

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