A Novel Herbal Combination Decreased Lipid Droplets Accumulation and Cytokines Levels during Adipogenesis by Regulating Leptin, PPARγ and SREBP1c Genes Expression in 3T3L1 Cells
Gorantla V. Bolla S. Tuladhar S. Bishir M. Mahalakshmi A.
January-March 2021Wolters Kluwer Medknow Publications
International Journal of Nutrition, Pharmacology, Neurological Diseases
2021#11Issue 150 - 56 pp.
The present study aims at demonstrating the anti-Adipogenesis and anti-inflammatory of combination of extracts of commiphora wightti, curcuma longa, and tinospora cordifolia using mouse 3T3-L1 cells. Herbal formula (CCT) significantly suppressed the mRNA of PPARγ, leptin, and SREBP1c expression, which is reveals its significant anti-Adipogenesis activity. In addition, CCT down-regulated TNFα and iNOS expression, this is an added advantage and helps to alleviate the inflammatory reactions during adipogenesis. These findings encourage for further studies using in vivo models of obesity and associated complications.
anti-Adipogenesis , Commiphora wightti , curcuma longa , tinospora cordifolia
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Department of Anatomical Sciences, School of Medicine, St. Georges University, Grenada, West Indies, India
Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Nur-Sultan, Kazakhstan
Department of Pharmacology, Jss College of Pharmacy, Jss Academy of Higher Education and Research, Mysuru, India
Department of Anatomical Sciences
Department of Biomedical Sciences
Department of Pharmacology
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