Crystal structure and Hirshfeld surface analysis of 3-(hydroxymethyl)-3-methyl-2,6-diphenylpiperidin-4-one
Gümüs M.K. Kansiz S. Tulemisova G.B. Dege N. Saif E.
1 January 2022International Union of Crystallography
Acta Crystallographica Section E: Crystallographic Communications
2022#7829 - 32 pp.
A new synthesis of the title compound, C19H21NO2, was developed with good yield and purity using the reaction of 4-hydroxy-3-methyl-2-butanone, benzaldehyde and ammonium acetate in glacial acetic acid as a solvent. The central piperidine ring adopts a chair conformation, and its least-squares basal plane forms dihedral angles of 85.71 (11) and 77.27 (11)° with the terminal aromatic rings. In the crystal, the molecules are linked by O-H⋯O and C-H⋯O hydrogen bonds into double ribbons. The Hirshfeld surface analysis shows that the most important contributions are from H⋯H (68%), C⋯H/H⋯C (19%) and O⋯H/H⋯O (12%) interactions.
4-hydroxy-3-methyl-2-butanone , Ammonium acetate , Benzaldehyde , Crystal structure , Hirshfeld surface , Hydrogen bonding , Piperidone
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Science-Technology Research and Application Center, Artvin Coruh University, Artvin, Turkey
Department of Chemistry and Chemical Technologies, Faculty of Natural and Agricultural Sciences, Atyrau State University named after Kh. Dosmukhamedov, Atyrau, 060011, Kazakhstan
Samsun University, Faculty of Engineering, Department of Fundamental Sciences, Samsun, 55420, Turkey
Ondokuz Mayis University, Faculty of Arts and Sciences, Department of Physics, Samsun, 55139, Turkey
Department of Computer and Electronic Engineering Technology, Sanaa Community College, Sanaa, Yemen
Department of Electrical and Electronic Engineering, Faculty of Engineering, Ondokuz Mayis University, Samsun, 55139, Turkey
Science-Technology Research and Application Center
Department of Chemistry and Chemical Technologies
Samsun University
Ondokuz Mayis University
Department of Computer and Electronic Engineering Technology
Department of Electrical and Electronic Engineering
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