Impact of carbon fluoroxide nanoparticles on cell proliferation
Géloën A. Mussabek G. Kharin A. Serdiuk T. Alekseev S.A. Lysenko V.
December 2021MDPI
Nanomaterials
2021#11Issue 12
Cytotoxicity of fluorescent carbon fluoroxide (CFO) nanoparticles (NPs) was studied in a label-free manner on several cancer and non-cancer cell lines. A direct cytotoxic effect of the CFO NPs was clearly observed by a suppression of cell proliferation. The real-time measurement of cell activities allowed to quantify the impact of the uptaken NPs on cell proliferation and after washout of the NPs from the cell culture medium. The results show more toxic effects of the CFO NPs on cancer than on non-cancer cell lines. The notion of NPs biocompatibility must be related to a maximum concentration value of the NPs acceptable for a given cell type. Furthermore, the cytotoxicity effects of NPs should be studied not only during their direct exposure to cells but also after their washout from the culture medium.
Cancer cell , Cellular uptake , Cytotoxicity , Nanoparticles , XCELLigence
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UMR Ecologie Microbienne Lyon (LEM), CNRS 5557, INRAE 1418, VetAgro Sup, Research Team “Bacterial Opportunistic Pathogens and Environment” (BPOE), Université Claude Bernard Lyon 1, Villeurbanne, 69622, France
Faculty of Physics and Technology, Al-Farabi Kazakh National University, 71, al-Farabi Ave., Almaty, 050040, Kazakhstan
Institute of Information and Computational Technologies, 125, Pushkin Str., Almaty, 050000, Kazakhstan
Institute of Engineering Physics for Biomedicine, Laboratory “Bionanophotonics”, National Research Nuclear University “MEPhI”, Kashirskoe sh. 31, Moscow, 115409, Russian Federation
Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, CH-8093, Switzerland
Chemistry Department, Taras Shevchenko National University of Kyiv, Volodymyrska Street, 64, Kyiv, 01601, Ukraine
Light Matter Institute, UMR-5306, Claude Bernard University of Lyon, 2 rue Victor Grignard, Villeurbanne, 69622, France
UMR Ecologie Microbienne Lyon (LEM)
Faculty of Physics and Technology
Institute of Information and Computational Technologies
Institute of Engineering Physics for Biomedicine
Institute of Molecular Systems Biology
Chemistry Department
Light Matter Institute
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