Phytochemical Profiling of Mentha asiatica Boriss. Leaf Extracts: Antioxidant and Antibacterial Activities

Gazizova A. Datkhayev U. Amirkhanova A. Ustenova G. Kozhanova K. Ikhsanov Y. Kapsalyamova E. Kadyrbayeva G. Allambergenova Z. Kantureyeva A. Baidullayeva A. Öztürk M. Berdgaleyeva A.
March 2025 Engineered Science Publisher

ES Food and Agroforestry
2025 #19

This study examines the phytochemical composition and antioxidant properties of Mentha asiatica Boriss. leaves, valued for their medicinal applications in Central Asia. Using Soxhlet apparatus ethanol extraction (SAE), vortex-assisted ethanol extraction (VAE), ultrasound-assisted ethanol extraction (UAE), and hydrodistillation, followed by gas chromatography–mass spectrometry (GC-MS) analysis, a variety of bioactive compounds were identified, including alkanes, ketones, terpenes, and fatty acids. Piperitenone oxide was the predominant component across all extraction methods (49.29%–87.65%). The antimicrobial properties of alkanes and ketones, attributed to their ability to disrupt microbial membranes, highlight their potential in antimicrobial formulations. UAE ethanol extract demonstrated the highest antioxidant activity, evaluated via 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays, and exhibited potent antimicrobial effects, with minimum inhibitory concentrations of 0.012 mg/mL against Candida albicans and 0.15 mg/mL against Pseudomonas aeruginosa. These findings underscore the potential of M. asiatica Boriss. as a source of natural antioxidants and antimicrobial agents. Advanced optimization strategies, such as response surface modeling, could further enhance the extraction efficiency and bioactivity. Future research should explore uncharacterized compounds to maximize therapeutic potential, emphasizing M. asiatica Boriss. as a valuable source of bioactive molecules for oxidative stress mitigation and infectious disease control.

Asian mint , Circulatory extraction , GC-MS , Mentha asiatica Boriss. extraction , Ultrasound extraction , Vortex extraction

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School of Pharmacy, S.D. Asfendiyarov Kazakh National Medical University, Tole-bi 94, Almaty, 050012, Kazakhstan
Department of Chemistry and Technology of Organic Substances, Natural Compounds and Polymers, Faculty of Chemistry and chemical technology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Department of Chemistry, Mugla Sitki Kocman University, Muğla, 48121, Turkey
Department of Pharmaceutical Disciplines, Marat Ospanov West Kazakhstan Medical University, Maresyev 68, Aktobe, 030019, Kazakhstan

School of Pharmacy
Department of Chemistry and Technology of Organic Substances
Department of Chemistry
Department of Pharmaceutical Disciplines

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