Sleep, Dietary Melatonin Supplementation, and COVID-19
Gasmi A. Semenova Y. Noor S. Benahmed A.G. Bjørklund G.
2024Bentham Science Publishers
Current Medicinal Chemistry
2024#31Issue 111298 - 1314 pp.
Background: During the COVID-19 pandemic, people suffered from major mental health problems. These include stress, anxiety, and confusion about the existing situation of home confinement. Melatonin is a popular anti-inflammatory and antioxidant molecule sold as an over-the-counter dietary supplement. Objective: This review discusses the indications for using melatonin in the context of the COVID-19 pandemic, including treatment. Methods: A comprehensive search of publications was conducted in electronic databases focusing on the administration of melatonin in COVID-19. Results: Stress has a huge negative impact on sleep routines and the quality of life of individuals. Sleep is considered an important modulator of the immune response. Thus, a lack of sleep can weaken immunity, increasing organism susceptibility to infection. For instance, shorter sleep durations are associated with a rise in suffering from the common cold. The administration of melatonin protects against viral and other pathogens and speeds clinical recovery. Conclusion: In patients admitted to intensive care units, melatonin decreases the risks of severe complications, such as thrombosis and sepsis, and mortality rates. In addition, it is efficacious in lowering vessel permeability, depression, and sedation, and improving the quality of sleep, which could also help COVID-19 patients achieve better clinical out-comes.
antioxidant , COVID-19 , dietary supplement , melatonin , sleep quality , stress
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Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, France
Nazarbayev University School of Medicine, Astana, Kazakhstan
Institute of Molecular Biology and Biotech-nology, Bahauddin Zakariya University, Multan, Pakistan
Department of Research, Académie Internatio-nale de Médecine Dentaire Intégrative, Paris, France
Department of Research, Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway
Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée
Nazarbayev University School of Medicine
Institute of Molecular Biology and Biotech-nology
Department of Research
Department of Research
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