Relationship between gut microbiota, gut hyperpermeability and obesity
Gasmi A. Mujawdiya P.K. Pivina L. Doşa A. Semenova Y. Benahmed A.G. Bjørklund G.
2021Bentham Science Publishers
Current Medicinal Chemistry
2021#28Issue 4827 - 839 pp.
Intestinal hyperpermeability is a complex metabolic process mediated by different pathways in close relation to the gut microbiota. Previous studies suggested that the gut microbiota is in-volved in different metabolic regulations, and its imbalance is associated with several metabolic dis-eases, including obesity. It is well known that intestinal hyperpermeability is associated with dysbio-sis, and the combination of these two conditions can lead to an increase in the level of low-grade inflammation in obese patients due to an increase in pro-inflammatory cytokine levels. Inflammatory bowel syndrome often accompanies this condition causing an alteration of the intestinal mucosa and thus reinforcing the dysbiosis and gut hyperpermeability. The onset of metabolic disorders depends on violations of the integrity of the intestinal barrier as a result of increased intestinal permeability. Chronic inflammation due to endotoxemia is responsible for the development of obesity. Metabolic disorders are associated with dysregulation of the microbiota-gut-brain axis and with an altered composition of gut flora. In this review, we will discuss the mechanisms that illustrate the relationship between hyperpermeability, the composition of the gut microbiota, and obesity.
Gut inflammation , Gut microbiota , Intestinal hyperpermeability , Metabolic , Metabolic regula-tion , Obesity
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Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, France
Birla Institute of Technology and Science-Pilani, Hyderabad, India
Semey Medical University, Semey, Kazakhstan
CONEM Kazakhstan Environmental Health and Safety Research Group, Semey Medical University, Semey, Kazakhstan
Faculty of Medicine, Ovidius University of Constanta, Constanta, Romania
Académie Inter-nationale de Médecine Dentaire Intégrative, Paris, France
Council for Nutritional and Environmental Medicine (CONEM), Toften 24, Mo i Rana, 8610, Norway
Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée
Birla Institute of Technology and Science-Pilani
Semey Medical University
CONEM Kazakhstan Environmental Health and Safety Research Group
Faculty of Medicine
Académie Inter-nationale de Médecine Dentaire Intégrative
Council for Nutritional and Environmental Medicine (CONEM)
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