Pharmacological Treatments and Natural Biocompounds in Weight Management
Gasmi A. Mujawdiya P.K. Nehaoua A. Shanaida M. Semenova Y. Piscopo S. Menzel A. Voloshyn V. Voloshyn O. Shanaida V. Bjørklund G.
February 2023MDPI
Pharmaceuticals
2023#16Issue 2
The obesity pandemic is one of society’s most urgent public health concerns. One-third of the global adult population may fall under obese or overweight by 2025, suggesting a rising demand for medical care and an exorbitant cost of healthcare expenditure in the coming years. Generally, the treatment strategy for obese patients is largely patient-centric and needs dietary, behavioral, pharmacological, and sometimes even surgical interventions. Given that obesity cases are rising in adults and children and lifestyle modifications have failed to produce the desired results, the need for medical therapy adjunct to lifestyle modifications is vital for better managing obesity. Most existing or past drugs for obesity treatment target satiety or monoamine pathways and induce a feeling of fullness in patients, while drugs such as orlistat are targeted against intestinal lipases. However, many medications targeted against neurotransmitters showed adverse events in patients, thus being withdrawn from the market. Alternatively, the combination of some drugs has been successfully tested in obesity management. However, the demand for novel, safer, and more efficacious pharmaceutical medicines for weight management does exist. The present review elucidates the current understanding of the available anti-obesity medicines of synthetic and natural origin, their main mechanisms of action, and the shortcomings associated with current weight management drugs.
metabolic syndrome , natural compounds , obesity , synthetic drugs
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Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, 69100, France
Research Department, Precision Health International, Ain Oulmene, 19200, Algeria
Inochi Care Private Limited, New Delhi, 110017, India
Laboratory of Physical Activity Sciences and Public Health, Mohamed Lamine Debaghine Sétif 2 University, Setif, 19000, Algeria
I. Horbachevsky Ternopil National Medical University, Ternopil, 46001, Ukraine
Nazarbayev University School of Medicine, Astana, 010000, Kazakhstan
Department of Nutritional Research and Development, Nutri-Logics SA, Weiswampach, 9990, Luxembourg
Laboratoires Réunis, Junglinster, 6131, Luxembourg
Ternopil Volodymyr Hnatiuk National Pedagogical University, Ternopil, 46027, Ukraine
Ternopil Ivan Puluj National Technical University, Ternopil, 46001, Ukraine
Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, 8610, Norway
Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée
Research Department
Inochi Care Private Limited
Laboratory of Physical Activity Sciences and Public Health
I. Horbachevsky Ternopil National Medical University
Nazarbayev University School of Medicine
Department of Nutritional Research and Development
Laboratoires Réunis
Ternopil Volodymyr Hnatiuk National Pedagogical University
Ternopil Ivan Puluj National Technical University
Council for Nutritional and Environmental Medicine (CONEM)
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