Obesity and insulin resistance: associations with chronic inflamma-tion, genetic and epigenetic factors
Gasmi A. Noor S. Menzel A. Doşa A. Pivina L. Bjørklund G.
2021Bentham Science Publishers
Current Medicinal Chemistry
2021#28Issue 4800 - 826 pp.
Background: Obesity is known to be a multifactorial disease. In its pathogenesis, different factors such as chronic inflammation, oxidative stress, insulin resistance, genetic fac-tors, environmental effects, vegetative disturbance, and unbalanced nutrition play a significant role. Methodology: This study describes the association of obesity and insulin resistance with chronic inflammation, genetic, and epigenetic factors. Previous literature has been reviewed to explain the relation of obesity with those factors involved in chronic low-grade inflammation and insulin. Results: Obesity is associated with a decrease in ghrelin secretion, elevated plasma leptin lev-els, oxidative stress, increased macrophage phagocytic activity, and the induction of pro-inflammatory synthesis of cytokines and interferon-gamma. Obesity is linked to decreased levels of cytochrome P450 (CYP) enzymes and impaired detoxification processes. Deficiency of vitamins and minerals can also play a significant role in the development of oxidative stress and chronic inflammation in obesity. There is evidence of associations between a genetic pre-disposition to obesity in children with elevated levels of certain miRNAs. Conclusion: The purpose of the present review is an analysis of the multiple factors associated with obesity.
Chronic inflammation , Epigenetics , Genetic factors , Insulin resistance , Nutrition , Obesity
Text of the article Перейти на текст статьи
Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, France
Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan
Laboratoires Réunis, Junglinster, Luxembourg
Faculty of Medicine, Ovidius University of Constanta, Constanta, Romania
Semey Medical University, Semey, Kazakhstan
CONEM Kazakhstan Environmental Health and Safety Research Group, Semey Medical University, Semey, Kazakhstan
Council for Nutritional and Environmental Medicine (CONEM), Toften 24, Mo i Rana, 8610, Norway
Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée
Institute of Molecular Biology and Biotechnology
Laboratoires Réunis
Faculty of Medicine
Semey Medical University
CONEM Kazakhstan Environmental Health and Safety Research Group
Council for Nutritional and Environmental Medicine (CONEM)
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026