Coenzyme Q10 in aging and disease
Gasmi A. Bjørklund G. Mujawdiya P.K. Semenova Y. Piscopo S. Peana M.
2024Taylor and Francis Ltd.
Critical Reviews in Food Science and Nutrition
2024#64Issue 123907 - 3919 pp.
Coenzyme Q10 (CoQ10) is an essential component of the electron transport chain. It also acts as an antioxidant in cellular membranes. It can be endogenously produced in all cells by a specialized mitochondrial pathway. CoQ10 deficiency, which can result from aging or insufficient enzyme function, has been considered to increase oxidative stress. Some drugs, including statins and bisphosphonates, often used by older individuals, can interfere with enzymes responsible for endogenous CoQ10 synthesis. Oral supplementation with high doses of CoQ10 can increase both its circulating and intracellular levels and several clinical trials observed that its administration provided beneficial effects on different disorders such as cardiovascular disease and inflammation which have been associated with low CoQ10 levels and high oxidative stress. Moreover, CoQ10 has been suggested as a promising therapeutic agent to prevent and slow the progression of other diseases including metabolic syndrome and type 2 diabetes, neurodegenerative and male infertility. However, there is still a need for further studies and well-designed clinical trials involving a large number of participants undergoing longer treatments to assess the benefits of CoQ10 for these disorders.
aging , Coenzyme Q10 , disease
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Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, France
Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway
Birla Institute of Technology and Science -Pilani, Hyderabad, India
Nazarbayev University School of Medicine, Astana, Kazakhstan
Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, Sassari, Italy
Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée
Council for Nutritional and Environmental Medicine (CONEM)
Birla Institute of Technology and Science -Pilani
Nazarbayev University School of Medicine
Department of Chemical
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