Natural essential oils as a new therapeutic tool in colorectal cancer
Garzoli S. Alarcón-Zapata P. Seitimova G. Alarcón-Zapata B. Martorell M. Sharopov F. Fokou P.V.T. Dize D. Yamthe L.R.T. Les F. Cásedas G. López V. Iriti M. Rad J.S. Gürer E.S. Calina D. Pezzani R. Vitalini S.
December 2022BioMed Central Ltd
Cancer Cell International
2022#22Issue 1
Colorectal cancer (CRC) is the third most revalent type of cancer in the world and the second most common cause of cancer death (about 1 million per year). Historically, natural compounds and their structural analogues have contributed to the development of new drugs useful in the treatment of various diseases, including cancer. Essential oils are natural odorous products made up of a complex mixture of low molecular weight compounds with recognized biological and pharmacological properties investigated also for the prevention and treatment of cancer. The aim of this paper is to highlight the possible role of essential oils in CRC, their composition and the preclinical studies involving them. It has been reviewed the preclinical pharmacological studies to determine the experimental models used and the anticancer potential mechanisms of action of natural essential oils in CRC. Searches were performed in the following databases PubMed/Medline, Web of science, TRIP database, Scopus, Google Scholar using appropriate MeSH terms. The results of analyzed studies showed that EOs exhibited a wide range of bioactive effects like cytotoxicity, antiproliferative, and antimetastatic effects on cancer cells through various mechanisms of action. This updated review provides a better quality of scientific evidence for the efficacy of EOs as chemotherapeutic/chemopreventive agents in CRC. Future translational clinical studies are needed to establish the effective dose in humans as well as the most suitable route of administration for maximum bioavailability and efficacy. Given the positive anticancer results obtained from preclinical pharmacological studies, EOs can be considered efficient complementary therapies in chemotherapy in CRC.
Anticancer properties , Anticancer therapy , Apoptosis , Colorectal cancer , Cytotoxicity , Natural essential oils
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Department of Drug Chemistry and Technologies, University “Sapienza” of Rome, P.Le Aldo Moro 5, Rome, 00185, Italy
Clinical Biochemistry and Immunology Department, Faculty of Pharmacy, University of Concepción, VIII – Bio Bio Region, Concepción, Chile
Facultad de Ciencias de La Salud, Universidad San Sebastián, Lientur 1457, Concepción, 4080871, Chile
Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, 4070386, Chile
Research Institution “Chinese-Tajik Innovation Center for Natural Products”, National Academy of Sciences of the Republic of Tajikistan, Ayni 299/2, Dushanbe, 734063, Tajikistan
Department of Biochemistry, Faculty of Science, University of Bamenda, Bambili, 39, Cameroon
Antimicrobial and Biocontrol Agents Unit, Department of Biochemistry, Faculty of Science, University of Yaounde 1, Ngoa Ekelle, Yaounde, 812, Cameroon
Institute for Medical Research and Medicinal Plants Studies, Yaoundé, 13033, Cameroon
Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, Villanueva de Gállego (Saragossa), 50830, Spain
Instituto Agroalimentario de Aragón-IA2 (CITA-Universidad de Zaragoza), Saragossa, 50059, Spain
Department of Biomedical, Surgical and Dental Sciences, Università Degli Studi di Milano, Via G. Pascal 36, Milan, 20133, Italy
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
Faculty of Pharmacy, Department of Pharmacognosy, Sivas Cumhuriyet University, Sivas, Turkey
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, 200349, Romania
Phytotherapy Lab (PhT-Lab), Endocrinology Unit, Department of Medicine (DIMED), University of Padova, Via Ospedale 105, Padua, 35128, Italy
AIROB, Associazione Italiana Per la Ricerca Oncologica Di Base, Padua, Italy
Department of Agricultural and Environmental Sciences, Università Degli Studi di Milano, Via G. Celoria 2, Milan, 20133, Italy
Department of Drug Chemistry and Technologies
Clinical Biochemistry and Immunology Department
Facultad de Ciencias de La Salud
Faculty of Chemistry and Chemical Technology
Department of Nutrition and Dietetics
Research Institution “Chinese-Tajik Innovation Center for Natural Products”
Department of Biochemistry
Antimicrobial and Biocontrol Agents Unit
Institute for Medical Research and Medicinal Plants Studies
Department of Pharmacy
Instituto Agroalimentario de Aragón-IA2 (CITA-Universidad de Zaragoza)
Department of Biomedical
Facultad de Medicina
Faculty of Pharmacy
Department of Clinical Pharmacy
Phytotherapy Lab (PhT-Lab)
AIROB
Department of Agricultural and Environmental Sciences
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