STUDY OF THE CHEMICAL COMPOSITION AND ANTIMICROBIAL ACTIVITY OF SUBCRITICAL CO₂ EXTRACT FROM EUPHORBIA HUMIFUSA WILLD
Gani G. Datkhayev U. Zhakipbekov K. Mombekov S. Ashirov M. Rakhymbayev N. Seitova Z.
1 July 2025
Georgian medical news
2025Issue 364-365295 - 302 pp.
INTRODUCTION: One of the priority areas of development in pharmacy is the study of local plants possessing antimicrobial activity. In this regard, determining the chemical composition of the CO₂ extract of Euphorbia humifusa Willd. with the aim of identifying new promising compounds with antimicrobial and antifungal activity is a pressing issue. MATERIALS AND METHODS: Using subcritical carbon dioxide extraction, 23 g of CO₂ extract of Euphorbia humifusa Willd. was obtained. To determine the potential use of Euphorbia humifusa Willd., we analysed the composition of the extract using GC-MS and the antimicrobial activity obtained by CO₂ extraction. RESULTS: For the first time, a comprehensive study of the CO₂ extract from the aerial parts of Euphorbia humifusa Willd., collected during the flowering phase in the Bostandyk district of Almaty Region, was conducted. Using gas chromatography-mass spectrometry (GC/MS) with Wiley 7th edition and NIST02 libraries, 47 components were identified. CONCLUSIONS: The obtained CO₂ extract of Euphorbia humifusa Willd. can be used in pharmaceutical technology as a substance.
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Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Asfendiyarov Kazakh National Medical University
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