Production of Polylactide Nanoparticles Loaded With Isoniazid and Vitamin C: A Promising Candidate for the Treatment of Resistant Forms of Tuberculosis


Galiyeva A. Daribay A. Tabriz N. Tazhbayev Y.
15 December 2025John Wiley and Sons Inc

Journal of Polymer Science
2025#63Issue 245372 - 5382 pp.

Nowadays, the method of directed transport of drugs is becoming increasingly important in medicine and pharmacology. It allows for increasing the concentration of delivered substances in a certain place and blocking or severely limiting their accumulation in healthy organs and tissues. One of the promising drug carriers used in the development of controlled drug delivery systems is polylactic acid (PLA). We were interested in using biodegradable polymeric nanoparticles (NPs) loaded with isoniazid (INH) and vitamin C (VC) which have sustained action, targeted delivery, high efficacy, and low toxicity. It will help to expand the use of these simple drugs for the rapid treatment of multidrug-resistant forms of tuberculosis. Thus, in this work, PLA-INH-VC NPs were prepared by double emulsion method where several factors affecting particle size were investigated. TGA/DSC and IR spectroscopy studies identified the presence of molecularly dispersed drugs (INH and VC) in polylactide nanoparticles. VC was found to reduce the degradation of the polymer and thus prolonged the release of the drug from the polymer matrix. PLA-INH-VC nanoparticles were analyzed for mycobacterial activity and the nanoparticles were found to inhibit the growth of INH-resistant mycobacteria.

antituberculosis drug , multidrug-resistant tuberculosis , nanoparticles , polylactic acid

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Karaganda University Named After Academician E.A.Buketov, Karaganda, Kazakhstan
Karaganda Medical University, Karaganda, Kazakhstan

Karaganda University Named After Academician E.A.Buketov
Karaganda Medical University

10 лет помогаем публиковать статьи Международный издатель

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