Human Serum Albumin Nanoparticles: Synthesis, Optimization and Immobilization with Antituberculosis Drugs
Galiyeva A. Daribay A. Zhumagaliyeva T. Zhaparova L. Sadyrbekov D. Tazhbayev Y.
July 2023Multidisciplinary Digital Publishing Institute (MDPI)
Polymers
2023#15Issue 13
The aim of this study was to create nanoparticles of human serum albumin immobilized with anti-TB drugs (rifampicin, isoniazid) using the desolvation method. Central Composite Design (CCD) was applied to study the effect of albumin, urea, L-cysteine, rifampicin and isoniazid concentration on particle size, polydispersity and loading degree of the drugs. The optimized nanoparticles were spherical in shape with an average particle size of 216.7 ± 3.7 nm and polydispersity of 0.286 ± 4.9. The loading degree of rifampicin and isoniazid in the optimized nanoparticles were 44% and 27%, respectively. The obtained nanoparticles were examined by Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC); the results showed the absence of drug–polymer interactions. The drug release from the polymer matrix was studied using dialysis membranes.
albumin , antituberculosis drugs , desolvation , isoniazid , nanoparticles , rifampicin
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Institute of Chemical Problems, Karagandy University of the Name of Academician E.A. Buketov, Karaganda City, 100028, Kazakhstan
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