The prognostic value of mean platelet volume in patients with coronary artery disease: An updated systematic review with meta-analyses
Galimzhanov A. Tun H.N. Sabitov Y. Perone F. Kursat T.M. Tenekecioglu E. Mamas M.A.
December 2024John Wiley and Sons Inc
European Journal of Clinical Investigation
2024#54Issue 12
Background: Mean platelet volume (MPV) is a widely available laboratory index, however its prognostic significance in patients with coronary artery disease (CAD) is still unclear. We intended to investigate and pool the evidence on the prognostic utility of admission MPV in predicting clinical outcomes in patients with CAD. Methods: PubMed, Web of Science, and Scopus were the major databases used for literature search. The risk of bias was assessed using the quality in prognostic factor studies. We used random-effects pairwise analysis with the Knapp and Hartung approach supported further with permutation tests and prediction intervals (PIs). Results: We identified 52 studies with 47,066 patients. A meta-analysis of nine studies with 14,864 patients demonstrated that one femtoliter increase in MPV values was associated with a rise of 29% in the risk of long-term mortality (hazard ratio [HR] 1.29, 95% confidence interval [CI] 1.22–1.37) in CAD as a whole. The results were further supported with PIs, permutation tests and leave-one-out sensitivity analyses. MPV also demonstrated its stable and significant prognostic utility in predicting long-term mortality as a linear variable in patients treated with percutaneous coronary intervention (PCI) and presented with acute coronary syndrome (ACS) (HR 1.29, 95% CI 1.20–1.39, and 1.29, 95% CI 1.19–1.39, respectively). Conclusion: The meta-analysis found robust evidence on the link between admission MPV and the increased risk of long-term mortality in patients with CAD patients, as well as in patients who underwent PCI and patients presented with ACS.
mean platelet volume; coronary artery disease , mortality , prognosis , systematic review
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Department of Propedeutics of Internal Disease, Semey Medical University, Semey, Kazakhstan
Keele Cardiovascular Research Group, Keele University, Keele, United Kingdom
Larner College of Medicine, University of Vermont, Burlington, VT, United States
Emergency Hospital, Semey, Kazakhstan
Cardiac Rehabilitation Unit, Rehabilitation Clinic “Villa delle Magnolie”, Caserta, Italy
Faculty of Medicine, Department of Cardiology, Marmara University, Istanbul, Turkey
Department of Cardiology, Bursa Yuksek İhtisas Training and Research Hospital, Health Sciences University, Bursa, Turkey
Department of Cardiology, Erasmus MC, Thorax Center, Erasmus University, Rotterdam, Netherlands
National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, United Kingdom
Department of Propedeutics of Internal Disease
Keele Cardiovascular Research Group
Larner College of Medicine
Emergency Hospital
Cardiac Rehabilitation Unit
Faculty of Medicine
Department of Cardiology
Department of Cardiology
National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre
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